Dynamics and Efficiency of Hole Transport in LNA:DNA Hybrid Diblock Oligomers
| Autor: | Arun K. Thazhathveetil, A. Trifonov, Michael R. Wasielewski, Joshua Vura-Weis, Frederick D. Lewis |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Purine
Pyrimidine Stereochemistry Charge separation Inverted Repeat Sequences Oligonucleotides Nucleic Acid Hybridization Quantum yield DNA General Chemistry Molecular Dynamics Simulation Circular dichroism spectra Biochemistry Catalysis chemistry.chemical_compound Colloid and Surface Chemistry Reaction rate constant chemistry Nucleic Acid Conformation Locked nucleic acid |
| Zdroj: | Journal of the American Chemical Society. 134:16434-16440 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja307989t |
| Popis: | We report here the effect of replacing one or both of the purine or pyrimidine blocks of a diblock stilbene donor-acceptor capped hairpin with locked nucleic acid (LNA) bases on the dynamics and efficiency of hole transport. The structures of the DNA and LNA:DNA hybrids are tentatively assigned to B- or A-type structures on the basis of their circular dichroism spectra. Replacing the bases in either the A-block or the G-block of the diblock DNA hairpin with LNA bases results in a modest decrease in the base-to-base hopping rate constant and quantum yield for charge separation. Somewhat larger decreases are observed when all of the purine or pyrimidine bases are replaced by LNA bases. |
| Databáze: | OpenAIRE |
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