Research advances on neurite outgrowth inhibitor B receptor
| Autor: | Ji-Feng Guo, Bei‐sha Tang, Rui Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Glycosylation Vascular smooth muscle Neurite Angiogenesis NgBR Parkinson's disease Nogo Proteins Cell Reviews Receptors Cell Surface Review Biology medicine.disease_cause Nervous System Vascular remodelling in the embryo angiogenesis 03 medical and health sciences 0302 clinical medicine Dolichols medicine Animals Humans Receptor Research Biological Transport Cell Biology Lipid Metabolism tumorigenesis Cell Transformation Neoplastic Cholesterol 030104 developmental biology medicine.anatomical_structure cholesterol trafficking Gene Expression Regulation Reticulon 030220 oncology & carcinogenesis Cancer research NUS1 Molecular Medicine Disease Susceptibility Carcinogenesis Protein Binding Signal Transduction |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| Popis: | Neurite outgrowth inhibitor‐B (Nogo‐B) is a membrane protein which is extensively expressed in multiple organs, especially in endothelial cells and vascular smooth muscle cells of blood vessels and belongs to the reticulon protein family. Notably, its specific receptor, Nogo‐B receptor (NgBR), encoded by NUS1, has been implicated in many crucial cellular processes, such as cholesterol trafficking, lipid metabolism, dolichol synthesis, protein N‐glycosylation, vascular remodelling, angiogenesis, tumorigenesis and neurodevelopment. In recent years, accumulating studies have demonstrated the statistically significant changes of NgBR expression levels in human diseases, including Niemann‐Pick type C disease, fatty liver, congenital disorders of glycosylation, persistent pulmonary hypertension of the newborn, invasive ductal breast carcinoma, malignant melanoma, non‐small cell lung carcinoma, paediatric epilepsy and Parkinson's disease. Besides, both the in vitro and in vivo studies have shown that NgBR overexpression or knockdown contribute to the alteration of various pathophysiological processes. Thus, there is a broad development potential in therapeutic strategies by modifying the expression levels of NgBR. |
| Databáze: | OpenAIRE |
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