Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia
| Autor: | Puneeta Tandon, Sathiyanarayanan Viswanathan, Koravangattu Sankaran, Anurag Saxena, Oksana Moshynska, David P. Sheridan |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Antineoplastic Agents Hormonal Chronic lymphocytic leukemia Gastroenterology Bcl-2-associated X protein Prednisone hemic and lymphatic diseases Internal medicine Proto-Oncogene Proteins Antineoplastic Combined Chemotherapy Protocols medicine Humans Antineoplastic Agents Alkylating Aged Neoplasm Staging bcl-2-Associated X Protein Aged 80 and over Hematology Chlorambucil biology business.industry Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Neoplasm Proteins Blot Leukemia Treatment Outcome Proto-Oncogene Proteins c-bcl-2 ROC Curve Apoptosis Immunology biology.protein Myeloid Cell Leukemia Sequence 1 Protein Female business medicine.drug |
| Zdroj: | American journal of hematology. 75(1) |
| ISSN: | 0361-8609 |
| Popis: | Although both Bcl-2/Bax ratio and Mcl-1 have been identified to be of clinical relevance in B-cell chronic lymphocytic leukemia (CLL), there is controversy regarding their role; further, their relative importance is not well delineated. Expression of Bcl-2, Bax, the Bcl-2/Bax ratio, and Mcl-1 in 51 consecutive previously untreated CLL patients and 16 controls was determined by Western blotting. Only 37 patients were treated, all with chlorambucil and prednisone initially. Six patients achieved complete response (CR), 14 were non-responders (NR), and 17 had a partial response (PR), as defined by NCI criteria. There was considerable inter-patient variability in protein expression and overlap with healthy volunteers (P > 0.05). All patients with CR had low Mcl-1 levels compared to the PR + NR group (0.07 +/- 0.02 vs. 0.14 +/- 0.07, P = 0.043). Higher Mcl-1 expression as determined by dichotomizing the data was associated with a failure to achieve CR (P = 0.021). The Bcl-2/Bax ratio was significantly associated with treatment response only when CR and PR were considered together (0.89 +/- 0.53 [CR + PR] vs. 3.38 +/- 4.47 [NR], P = 0.0118). There was no association with Rai stage. Low Mcl-1 appears to be a requirement for CR, while low Bcl-2/Bax ratio is indicative of some response to conventional treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text