Clinical Profile of Critical Pertussis in Children at a Pediatric Intensive Care Unit in Northern India
| Autor: | Lucky Sangal, Madhusudan Samprathi, T. K. Kavitha, Vikas Gautam, Muralidharan Jayashree |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Apnea Whooping Cough Critical Illness medicine.medical_treatment Encephalopathy India Exchange transfusion Intensive Care Units Pediatric Hypoxemia Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Intensive care Pediatric surgery medicine Humans 030212 general & internal medicine Child Outcome Retrospective Studies Mechanical ventilation Pediatric intensive care unit business.industry Infant Prognosis medicine.disease Child Preschool Pediatrics Perinatology and Child Health Immunization Female medicine.symptom business DPT vaccine Research Paper |
| Zdroj: | Indian Pediatrics |
| ISSN: | 0974-7559 0019-6061 |
| DOI: | 10.1007/s13312-020-1756-3 |
| Popis: | Objective To delineate the clinical profile, complications, intensive care needs, and predictors of mortality in children with critical pertussis. Methods Retrospective analysis of case records of children in the pediatric intensive care unit of a tertiary-care hospital, with a diagnosis of critical pertussis over 3 years. Diagnostic criteria included CDC case definition and confirmation by polymerase chain reaction (PCR), when available. Survivors and non-survivors were compared to identify predictors of mortality. Results 36 records were analysed, most cases were infants (31, 86.1%). 10 (27.7%) were (below 6 weeks of age). In the rest, 16 (61.5%) were partially immunized or unimmunized against pertussis. Rapid breathing (88.9%), paroxysmal cough (86.1%) and apnea (41.7%) were common presenting complaints. Hypoxemia (97.2%), hyperleukocytosis (61.1%) and encephalopathy (52.8%) were common complications. Intensive care needs were mechanical ventilation in 11 (30.6%), vasoactive support in 7 (19.4%) and exchange transfusion in 3 (8.3%). Female gender, apnea, hyperleukocytosis, encephalopathy, need for vasoactive support, and mechanical ventilation predicted mortality. Conclusions Pertussis demands attention due to its varied presentation, increased complications and higher mortality. |
| Databáze: | OpenAIRE |
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