Long non-coding RNA CEBPA-AS1 correlates with poor prognosis and promotes tumorigenesis via CEBPA/Bcl2 in oral squamous cell carcinoma
| Autor: | Li Zhu, Yuji Ma, Rongbo Song, Ming Zhong, Yan Guo, Xuanhao Hu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Keratinocytes Male Cancer Research Cytoplasm Carcinogenesis Apoptosis medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Cell Line Tumor CEBPA medicine Biomarkers Tumor Humans Stage (cooking) Survival rate Cell Proliferation Neoplasm Staging Pharmacology Oncogene Mechanism (biology) business.industry Mouth Mucosa Middle Aged Long non-coding RNA Up-Regulation Gene Expression Regulation Neoplastic stomatognathic diseases 030104 developmental biology Oncology Proto-Oncogene Proteins c-bcl-2 030220 oncology & carcinogenesis Lymphatic Metastasis Cancer research CCAAT-Enhancer-Binding Proteins Carcinoma Squamous Cell Molecular Medicine Female Mouth Neoplasms RNA Long Noncoding business Research Paper Signal Transduction |
| Popis: | Oral squamous cell carcinoma (OSCC) is one of the most aggressive and lethal malignancies affecting the head and neck region with a general 5-year survival rate about 50%. Long non-coding RNAs (lncRNAs) are believed to participate in diverse biological processes and are emerging as convenient and minimally invasive diagnostic/prognostic/therapeutic markers. The aim of this study was to explore CEBPA-AS1 role and mechanism in OSCC tumorigenesis. In this study, CEBPA-AS1 localized in the cytoplasm and the peri-nuclear cellular compartment functioning as a potential oncogene up-regulated in OSCC was correlated with poor differentiation, lymph node metastasis and high clinical stage, which made it considered to be a prognostic biomarker. Silence of CEBPA-AS1 inhibited OSCC cells proliferation and induced cells apoptosis, migration and invasion by targeting CEBPA and via a novel pathway CEBPA/Bcl2. Our findings provided the first evidence for the lncRNA CEBPA-AS1 regulatory network in OSCC tumorigenesis, which might be helpful to improve the effects of clinical treatment in OSCC. |
| Databáze: | OpenAIRE |
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