Development of nanoparticles coated with cassava bagasse pectin (Manihot esculenta Crantz) containing β-carotene for mucoadhesive applications
| Autor: | Clarissa Feltrin, Bianca Coelho, Marcelo Maraschin, Daniela Sousa Coelho, Enilto de Oliveira Neubert, Naira Fernanda Zanchett Schneider, Ana Paula Lorenzen Voytena, Cláudia Maria Oliveira Simões, Letícia Mazzarino, Heloisa da Silva Pitz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Manihot Pectin 030309 nutrition & dietetics medicine.medical_treatment cassava bagasse Science Dispersity 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology food β-carotene Mucoadhesion medicine Cellulose pectin 0303 health sciences Multidisciplinary biology Carotene 04 agricultural and veterinary sciences biology.organism_classification beta Carotene 040401 food science Bioavailability chemistry Pectins Manihot esculenta Crantz nanoparticles Particle size mucoadhesion Nuclear chemistry |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 92, Iss 4 (2020) Anais da Academia Brasileira de Ciências v.92 n.4 2020 Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências (ABC) instacron:ABC Anais da Academia Brasileira de Ciências, Volume: 92, Issue: 4, Article number: e20200134, Published: 20 NOV 2020 |
| ISSN: | 1678-2690 |
| Popis: | Pectin (PC) extracted from a solid residue from cassava roots (Manihot esculenta Crantz) was used to coat nanoparticles (NP) containing β-carotene (BC) aiming at the gastrointestinal administration of this lipophilic nutraceutical. The NP were prepared by spontaneous emulsification method using food grade components. Pectin-coated NP have been successfully prepared as confirmed by the increased particle size and negative surface charges due to the pectin’s anionic nature. NP showed spherical shape and monodisperse distribution, with a mean size of 21.3 nm (polydispersity index (PDI) 0.29) for BC PC T80-NP (nanoparticle with β-carotene, pectin and Tween 80) and 261.4 nm (PDI 0.1) for BC PC T20-NP (nanoparticle with β-carotene, pectin and Tween 20). BC was encapsulated at amounts of 530 and 324 µg/ml for BC PC T80-NP and BC PC T20-NP, respectively, with high encapsulation efficiency (> 95%), increasing its antioxidant capacity in vitro, besides no cytotoxic effect. However, only BC PC T20-NP was stable over a 90 days storage period (4°C) and revealed a strong interaction between pectin and mucin. These results suggest that pectin-coated BC PC T20-NP is a promising strategy to improve the bioavailability and permeation of BC for administration through mucosal surfaces. |
| Databáze: | OpenAIRE |
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