Thrombospondin-1 induced programmed death-ligand 1-mediated immunosuppression by activating the STAT3 pathway in osteosarcoma

Autor:	Zhuochao Liu, Junxiang Wen, Fangqiong Hu, Jun Wang, Chuanzhen Hu, Weibin Zhang
Rok vydání:	2021
Předmět:	STAT3 Transcription Factor Cancer Research Osteosarcoma Apoptosis Bone Neoplasms General Medicine CD8-Positive T-Lymphocytes B7-H1 Antigen Gene Expression Regulation Neoplastic Thrombospondin 1 Mice Oncology Cell Line Tumor Immune Tolerance Animals Humans Cell Proliferation Signal Transduction
Zdroj:	Cancer science. 113(2)
ISSN:	1349-7006
Popis:	Thrombospondin-1 (TSP1) is generally assumed to suppress the growth of osteosarcoma through inhibiting angiogenesis; however, it is unclear whether TSP1 could affect the antitumor immunity against osteosarcoma. We aimed to explore the immune-related tumor-promoting effects of TSP1 and decipher its underlying mechanism. First, we identified that TSP1 regulated programmed death-ligand 1 (PD-L1) expression, which was related to the CD8
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40eb1e0e278af61bbc801ecee4520039 https://pubmed.ncbi.nlm.nih.gov/34927311 Zobrazit plný text záznamu Plný text