Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington’s disease
| Autor: | Xiaoyu Zhang, Christopher A. Ross, Adrian Paez, Martin Kronenbuerger, Russell L. Margolis, Jun Hua, Kia E. Ultz, Wenzhen Duan, Xinyuan Miao, Peter Klinkmueller, Jee Bang, Peter C.M. van Zijl |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Stimulation Disease 03 medical and health sciences 0302 clinical medicine Huntingtin Gene Huntington's disease medicine Cerebral Blood Volume Humans Cerebral oxygen metabolism 030304 developmental biology Brain Mapping 0303 health sciences business.industry Triplet repeat Neurodegeneration Brain Neurodegenerative Diseases Original Articles Middle Aged medicine.disease Magnetic Resonance Imaging Oxygen Cross-Sectional Studies Early Diagnosis Huntington Disease Neurology Case-Control Studies Cerebrovascular Circulation Cancer research Biomarker (medicine) Female Occipital Lobe Neurology (clinical) Cardiology and Cardiovascular Medicine business Biomarkers Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | J Cereb Blood Flow Metab |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1177/0271678x20949286 |
| Popis: | Huntington’s disease (HD) is a neurodegenerative disease caused by a CAG triplet repeat expansion in the Huntingtin gene. Metabolic and microvascular abnormalities in the brain may contribute to early physiological changes that subserve the functional impairments in HD. This study is intended to investigate potential abnormality in dynamic changes in cerebral blood volume (CBV) and cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2) in the brain in response to functional stimulation in premanifest and early manifest HD patients. A recently developed 3-D-TRiple-acquisition-after-Inversion-Preparation magnetic resonance imaging (MRI) approach was used to measure dynamic responses in CBV, CBF, and CMRO2 during visual stimulation in one single MRI scan. Experiments were conducted in 23 HD patients and 16 healthy controls. Decreased occipital cortex CMRO2 responses were observed in premanifest and early manifest HD patients compared to controls ( P 2 = 0.4, P = 0.001). The results suggest the potential value of this reduced CMRO2 response during visual stimulation as a biomarker for HD and may illuminate the role of metabolic alterations in the pathophysiology of HD. |
| Databáze: | OpenAIRE |
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