Caspase-3 inhibitor inhibits enterovirus D68 production
| Autor: | Shucheng Hua, Fengmei Song, Chunyu Liu, Jinming Liu, Ting Wu, Xiaoyan Yu, Wenbo Huo, Yue Wang, Yumeng Liu, Jinghua Yu, Xiangling Meng, Ying Su, Shuxia Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
caspase-3
Host–pathogen interaction Caspase 3 host-pathogen interaction Applied Microbiology and Biotechnology Microbiology Antiviral Agents Virus Piperazines 03 medical and health sciences Immune system Virology Cell Line Tumor Enterovirus Infections Humans Caspase 030304 developmental biology Enterovirus D Human 0303 health sciences biology 030306 microbiology Activator (genetics) apoptosis viral production Hydrazones Outbreak General Medicine G1 Phase Cell Cycle Checkpoints EVD68 Apoptosis biology.protein Oligopeptides |
| Zdroj: | Journal of Microbiology (Seoul, Korea) |
| ISSN: | 1976-3794 1225-8873 |
| Popis: | Enterovirus D68 (EVD68) is an emerging pathogen that recently caused a large worldwide outbreak of severe respiratory disease in children. However, the relationship between EVD68 and host cells remains unclear. Caspases are involved in cell death, immune response, and even viral production. We found that caspase-3 was activated during EVD68 replication to induce apoptosis. Caspase-3 inhibitor (Z-DEVD-FMK) inhibited viral production, protected host cells from the cytopathic effects of EVD68 infection, and prevented EVD68 from regulating the host cell cycle at G0/G1. Meanwhile, caspase-3 activator (PAC-1) increased EVD68 production. EVD68 infection therefore activates caspase-3 for virus production. This knowledge provides a potential direction for the prevention and treatment of disease related to EVD68. |
| Databáze: | OpenAIRE |
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