Dose-related effects of theophylline added to modified euro-collins solution used for hypothermic preservation of lung
| Autor: | Sukru Dilege, Korkut Bostanci, Mehmet Tugrul, Alper Toker, Mert Şentürk, Yusuf Bayrak, Gülçin Aykaç-Toker |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.drug_class
Hypertonic Solutions Pharmacology Lipid peroxidation chemistry.chemical_compound Theophylline Hypothermia Induced Malondialdehyde Bronchodilator Collins' solution Animals Medicine Rats Wistar Respiratory system Lung Dose-Response Relationship Drug business.industry University hospital Bronchodilator Agents Rats Anesthesiology and Pain Medicine medicine.anatomical_structure chemistry Reperfusion Injury Anesthesia Lipid Peroxidation Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia. 17:721-724 |
| ISSN: | 1053-0770 |
| DOI: | 10.1053/j.jvca.2003.09.011 |
| Popis: | To investigate the dose-related effects of theophylline in prevention of ischemia-reperfusion injury of the lung.Experimental study.University hospital.Thirty Wistar rats.In experimental group 1 (G-I) (n = 5) 20 mg/L, in G-II (n = 5) 100 mg/L, in G-III (n = 5) 400 mg/L, and in G-IV (n = 5) 1000 mg/L of theophylline was added to modified Euro-Collins solution and perfused the lungs. Lungs were extracted without an ischemic period in control group 1 (C-I) and perfused with modified Euro-Collins solution in control group 2 (C-II). Lungs were kept in a hypothermic state for 6 hours and then ventilated for 30 minutes with 100% O(2).Tissue levels of dien congugate (DC) and malonylaldehyde (MDA) were measured. Comparison of 6 groups revealed statistically significant differences for DC and MDA (p0.0001 for both comparisons). Both DC and MDA levels of C-II were found to be higher than G-III and G-IV (p = 0.008). DC and MDA levels of G-III and G-IV were significantly lower than G-I and G-II (p = 0.008 for all comparisons).The results of this study showed that 400 mg/L and 1000 mg/L of theophylline added to the modified Euro-Collins solution decreased the intermediate products of lipid peroxidation. Theophylline merits further investigation in ischemia-reperfusion studies as a potentially beneficial agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect