The Behavioral Effects of Prenatal and Early Postnatal Lead Exposure in the Primate Ma Ca Ca Fascicularis
| Autor: | David L. Hopper, W. Eugene Lloyd, William J. Kernan |
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| Rok vydání: | 1986 |
| Předmět: |
Male
0301 basic medicine Offspring Health Toxicology and Mutagenesis Physiology 010501 environmental sciences Toxicology 01 natural sciences Discrimination Learning 03 medical and health sciences Fetus biology.animal Animals Primate Response inhibition 0105 earth and related environmental sciences Whole blood Behavior Animal Dose-Response Relationship Drug 030102 biochemistry & molecular biology biology Body Weight Public Health Environmental and Occupational Health Anatomy Macaca fascicularis Dose–response relationship Lead Lead exposure Toxicity Gestation Female |
| Zdroj: | Toxicology and Industrial Health. 2:1-16 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/074823378600200101 |
| Popis: | Female Macaca fascicularis monkeys were given daily oral doses of 3.0 and 4.25 mglkg lead, as lead nitrate, prior to breeding, and exposure was maintained throughout gestation and terminated at parturition. No overt signs of lead toxicity were observed in the maternal monkeys. The offspring were tested at 6 to 18 months of age on a three-choice non-spatial form discrimination paradigm, and at 19 to 26 months of age on a response inhibition task. When compared to controls, the lead-exposed infants showed a deficit in form discrimination performance which continued during the entire period of testing. A deficit in response inhibition performance was also observed in exposed infants when compared to controls. How ever, the deficit was temporary, as the performance of all groups was similar at the termination of testing. The observation of a per sistent deficit in form discrimination up to 18 months following the termination of exposure suggests that lead-induced behavioral changes may be permanent. These findings are cause for concern since behavioral deficits in the offspring were observed at maternal gestational whole blood lead levels within a concentration range (30 to 70 μg/dl) associated with occupational exposure. |
| Databáze: | OpenAIRE |
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