Identification of a Novel HIV-1 Second-Generation (CRF01_AE/B) Among Men Who Have Sex with Men in Tianjin, China
| Autor: | Yiming Shao, Zhanmou Liu, Ping Ma, Yanling Liang, Bowen Lv, Kang Li, Dan Liu, Weidong Ou, Yimam Getaneh, Zhangwen Ge |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
China Lineage (genetic) Genotype Immunology Population Human immunodeficiency virus (HIV) HIV Infections Genome Viral Biology medicine.disease_cause Genome law.invention Men who have sex with men Sexual and Gender Minorities immune system diseases law Virology medicine Humans Homosexuality Male education Phylogeny Recombination Genetic education.field_of_study Transmission (medicine) virus diseases Sequence Analysis DNA Genes pol Infectious Diseases HIV-1 Recombinant DNA |
| Zdroj: | AIDS Research and Human Retroviruses. 36:138-142 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2019.0187 |
| Popis: | In this study, we report a novel HIV-1 second-generation recombinant form composed of CRF01_AE and subtype B detected from a married HIV-positive male subject infected through homosexual behavior in Tianjin in northern China. The near full-length genome analyses showed that two regions of subtype B inserted into the CRF01_AE backbone with four recombinant breakpoints observed in the pol gene region. Subregion tree analyses demonstrated that the CRF01_AE regions of the recombinant were greatly clustered with the CRF01_AE subcluster 4 lineage, which was found primarily among men who have sex with men (MSM) in northern China. To the best of our knowledge, this is the first detection of a novel HIV-1 second-generation recombinant form (CRF01AE/B) in Tianjin, which indicates active transmission networks of HIV-1 infection among MSM in this region. The emergence of the novel second-generation recombinant form highlights the increasing complexity of HIV-1 epidemic among MSM population and the importance to monitor potential novel circulating recombinant forms. |
| Databáze: | OpenAIRE |
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