Studies on Improved Synthesis of 2'-Deoxyribonucleosides of Pyridazine Derivatives

Autor:	Flavio Meggio, Zygmunt Kazimierczuk, Jarosław Kamiński
Rok vydání:	2006
Předmět:	Glycosylation Deoxyribonucleosides Potassium chemistry.chemical_element General Medicine General Chemistry law.invention Pyridazine chemistry.chemical_compound Column chromatography chemistry law Nucleic acid Acetone Organic chemistry Crystallization
Zdroj:	Collection of Czechoslovak Chemical Communications. 71:889-898
ISSN:	1212-6950 0010-0765
DOI:	10.1135/cccc20060889
Popis:	A number of 2'-deoxyribonucleosides of halogenated pyridazine derivatives were prepared by glycosylation of their respective potassium or DBU salts in acetone. The reaction yielded predominatly β-anomers that could be purified by simple crystallization or column chromatography. Of the studied pyridazines and deoxynucleosides, only 4-bromo-6-chloropyridazin-3-one and 6-chloro-2-(2'-deoxyribofuranosyl)pyridazin-3-one showed modest inhibition of CK2 kinase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dc67baf55a05fd214f8d484fd331bd https://doi.org/10.1135/cccc20060889 Zobrazit plný text záznamu