Metallothionein and Fas (CD95) are expressed in squamous cell carcinoma of the tongue
| Autor: | Lena Norberg-Spaak, K. Sundelin, A. Davidsson, M. Jadner, H. B. Hellquist |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Apoptosis Biology medicine.disease_cause Jurkat cells medicine Carcinoma Humans fas Receptor Myoepithelial cell Cell Differentiation Middle Aged Fas receptor medicine.disease Immunohistochemistry Epithelium Tongue Neoplasms Ki-67 Antigen medicine.anatomical_structure Oncology Epidermoid carcinoma Carcinoma Squamous Cell Cancer research Female Metallothionein Carcinogenesis |
| Zdroj: | European Journal of Cancer. 33:1860-1864 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/s0959-8049(97)00216-5 |
| Popis: | Metallothionein (MT) is a chelator present in myoepithelial cells, whilst the Fas-receptor (APO-1, CD95) has been described primarily in human T Jurkat cells. 20 cases of carcinoma of the tongue were investigated immunocytochemically with regard to MT, Fas and Bcl-2. In normal oral squamous epithelium, MT is located in the basal/parabasal dividing cells only. In well-differentiated nests of carcinomas, MT is observed almost entirely in peripherally located cells. In situ end-labelling indicates apoptosis in the centre of these nests, but not in the peripheral areas. Less-differentiated areas show more general MT-positivity, but little apoptosis. All 24 tumours are Fas-positive, but normal epithelia are mainly negative (P< 0.0001). Bcl-2 protein was sparse in the tumours compared with MT and Fas (P< 0.0001). We thus suggest that MT, possibly due to its chelating properties, may contribute to delaying cells entering apoptosis, both in normal epithelium near the base and in less-differentiated regions of carcinoma. Moreover, Fas may be present in cells of human malignancies, as well as those of established malignant cell lines. |
| Databáze: | OpenAIRE |
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