Usefulness of panoramic 344°-viewing in Crohn's disease capsule endoscopy: a proof of concept pilot study with the novel PillCam™ Crohn's system
Autor: | G. Bonitta, D. Gelli, Gian Eugenio Tontini, Luca Pastorelli, Fernando Rizzello, Maurizio Vecchi, Carlo Calabrese, Paolo Gionchetti, Marco Salice, Flaminia Cavallaro |
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Přispěvatelé: | Tontini G.E., Rizzello F., Cavallaro F., Bonitta G., Gelli D., Pastorelli L., Salice M., Vecchi M., Gionchetti P., Calabrese C. |
Rok vydání: | 2019 |
Předmět: |
Enteroscopy
S system Adult Male Crohn’s disease medicine.medical_specialty Pilot Projects Disease Inflammatory bowel disease Capsule Endoscopy Proof of Concept Study Sensitivity and Specificity law.invention Lesion Crohn Disease Capsule endoscopy law Internal medicine PillCam™ Crohn's system medicine Humans lcsh:RC799-869 Pan-intestinal endoscopy Crohn's disease business.industry Gastroenterology General Medicine Hepatology Middle Aged medicine.disease Capsule Endoscopes lcsh:Diseases of the digestive system. Gastroenterology Female Radiology medicine.symptom PillCam™ Crohn’s system business Follow-Up Studies Research Article |
Zdroj: | BMC Gastroenterology BMC Gastroenterology, Vol 20, Iss 1, Pp 1-6 (2020) |
ISSN: | 1471-230X |
Popis: | Background A new capsule endoscopy (CE) system featuring two advanced optics for 344°-viewing and a prolonged operative time has been recently developed for Crohn’s disease (CD) patients. Hence, we evaluated, for the first time, the performance of this novel CE and the add-on value of the 344°-viewing in a multi-center real-life setting. Methods Consecutive patients with suspected or established CD received the PillCam™ Crohn’s System as supplementary diagnostic work-up focused on the small-bowel between June 2017 and June 2018. Technical and clinical data, including the panenteric CE diagnostic yield, the Lewis score and the impact of small-bowel findings on clinical management during a 6-months follow-up (new diagnosis, staging or treatment upgrade) were collected, thereby evaluating the added value of the 344° panoramic-view (lesions detected by camera A and B) over the standard 172°-view (lesions detected by one camera only). Results Among 41 patients (aged 43 ± 20 years), 73% underwent CE for suspected CD and 27% for established CD. The rate of complete enteroscopy was 90%. No technical failure or retention occurred. Compared to the standard 172° view, the panoramic 344°-view revealed a greater number of patients with a relevant lesion (56.1% vs. 39.0%; P = 0.023), resulting in higher Lewis score (222,8 vs. 185.7; P = 0.031), and improved clinical management (48.8% vs. 31.7%, P = 0.023). Conclusions The panoramic 344°-view increases small-bowel CE accuracy, thereby improving the clinical management of CD patients with mild small-bowel active disease. This system should be regarded as a new standard for both small-bowel diagnosis and monitoring in inflammatory bowel diseases. |
Databáze: | OpenAIRE |
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