Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency
| Autor: | Yutaka Shizuta, K Saika, Kiyoshi Takeda, T Onishi, Katsumi Toda, Tetsuro Sugiura, M Nakagawa, Toshiji Saibara |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Blood Glucose
Male Aging medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Intraperitoneal injection Carbohydrate metabolism Mice chemistry.chemical_compound Aromatase Endocrinology Insulin resistance Internal medicine medicine Animals Insulin Testosterone Obesity Triglycerides Mice Knockout Glucose tolerance test Estradiol Pioglitazone biology Triglyceride medicine.diagnostic_test Glucose Tolerance Test Androgen medicine.disease Thiazoles Cholesterol chemistry Models Animal biology.protein Thiazolidinediones Bezafibrate Insulin Resistance |
| Zdroj: | Journal of Endocrinology. 176:237-246 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.1760237 |
| Popis: | Aromatase (CYP19) is a cytochrome P450 enzyme that catalyzes the formation of aromatic C18 estrogens from C19 androgens. It is expressed in various tissues and contributes to sex-specific differences in cellular metabolism. We have generated aromatase-knockout (ArKO) mice in order to study the role of estrogen in the regulation of glucose metabolism. The mean body weights of male ArKO (-/-) mice (n=7) and wild-type littermates (+/+) (n=7) at 10 and 12 weeks of age were 26.7+/-1.9 g vs 26.1+/-0.8 g and 28.8+/-1.4 g vs 26.9+/-1.0 g respectively. The body weights of the ArKO and wild-type mice diverged between 10 and 12 weeks of age with the ArKO males weighing significantly more than their wild-type littermates (P |
| Databáze: | OpenAIRE |
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