Effect of pregnancy on anti-HEV antibody titres, plasma cytokines and the corresponding gene expression levels in the PBMCs of patients presenting with self-recovering clinical and subclinical hepatitis E

Autor: Ravi P. Arya, Vidya A. Arankalle, Ashwini Y. Ramdasi
Rok vydání: 2014
Předmět:
Male
lcsh:Medicine
Gene Expression
Pathogenesis
Liver Function Tests
Pregnancy
Blood plasma
Medicine and Health Sciences
Cluster Analysis
Pregnancy Complications
Infectious
lcsh:Science
Subclinical infection
Multidisciplinary
Liver Diseases
Hepatitis E
Medical Microbiology
Viral Pathogens
Chemokine secretion
Host-Pathogen Interactions
Viruses
Cytokines
Female
Antibody
Research Article
Adult
Gastroenterology and Hepatology
Biology
Microbiology
Young Adult
Immune system
medicine
Hepatitis E virus
Humans
Interleukin 8
Hepatitis Antibodies
Microbial Pathogens
Infectious Hepatitis
Gene Expression Profiling
lcsh:R
Organisms
Biology and Life Sciences
medicine.disease
Immunoglobulin M
Case-Control Studies
Immunoglobulin G
Immunology
biology.protein
Leukocytes
Mononuclear
lcsh:Q
Blood Chemical Analysis
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 8, p e103257 (2014)
ISSN: 1932-6203
Popis: High mortality in pregnant women (PR) is a characteristic of hepatitis E in developing countries. To understand the pathogenesis of HEV infection in self-limiting disease during pregnancy, we compared clinical (PR-patients) and subclinical-HEV-infections in pregnant women in the first (SC-PR-1) and later (2nd and 3rd, SC-PR-2+3) trimesters with the respective healthy controls and acute non-PR patients. The SC-PR-2+3 exhibited lower ALT, bilirubin levels, anti-HEV-IgM/IgG titres than the acute-PR/non-PR-patients (p
Databáze: OpenAIRE
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