Anthracycline-Induced Cardiotoxicity: The Role of Endothelial Dysfunction
| Autor: | E V Grakova, Sergey N Shilov, K. V. Kopeva, A T Teplyakov, Elena T Ratushnyak, Anna A Popova, Maria N Neupokoeva, Ekaterina N Berezikova |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Anthracycline Cardiomyopathy Breast Neoplasms 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Medicine Humans Pharmacology (medical) Doxorubicin Anthracyclines Endothelial dysfunction Cause of death Cardiotoxicity Antibiotics Antineoplastic business.industry Endothelial Cells medicine.disease Endothelin 1 Endothelial stem cell 030104 developmental biology Cancer research Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiology. 146(3) |
| ISSN: | 1421-9751 |
| Popis: | Cardiovascular disease remains the leading cause of mortality accounting up to 40% of all deaths, but, currently, cancer is prominent cause of death globally. Anthracyclines are the cornerstone of chemotherapy in women with breast cancer. However, its clinical use is limited by their cardiotoxic effects that can trigger heart failure development. Vascular toxicity of chemotherapy may be linked with endothelial dysfunction because anthracycline damage of endothelial cells can lead to the development and progression of cardiomyopathy by decreasing the release and activity of endothelial factors and, ultimately, endothelial cell death. These processes suppress anti-inflammatory and vascular reparative functions and initiate the development of future cardiovascular events. Recent studies have shown that chemotherapy may induce toxicity in the vascular endothelium and is accompanied by systemic endothelial dysfunction in patients with diagnosed cardiovascular diseases. Because the initial endothelial cell insult is likely asymptomatic, there is often a long delay between the termination of doxorubicin therapy and the onset of vascular disorders. In this case, genetic susceptibility factor will help to identify susceptible patients in the future. The objectives of this study were to evaluate prognostic role of molecular (endothelin-1) and genetic factors (gene polymorphisms of endothelial nitric oxide (NO) synthase (NOS3, rs1799983), endothelin-1 receptor type A (EDNRA, C+70G, rs5335) and NADPH oxidase (C242T, rs4673) in development of endothelial dysfunction and anthracycline-induced cardiotoxicity in women without cardiovascular diseases. |
| Databáze: | OpenAIRE |
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