COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study

Autor: Morena Brazil Sant'Anna, Cristiane F.G. Lima, Ruy F.M. Viégas, Matteo C. Ebram, Sonia A. Andrade, Gisele Picolo, Rosa M.G. Celano, Louise F. Kimura
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Neutrophils
medicine.medical_treatment
Comorbidity
Single Center
Gastroenterology
Severity of Illness Index
Hemoglobins
Leukocyte Count
Risk Factors
LDL
low-density lipoprotein
RT-PCR
real-time reverse transcription-polymerase chain reaction
Hemoglobin concentration
T2DM
Type 2 diabetes mellitus
Hypoxia
COVID-19
coronavirus disease 2019
Anemia
Hematology
TG
triglycerides
Middle Aged
Molecular Medicine
medicine.symptom
Lipoproteins
HDL
CVDs
cardiovascular diseases
Artificial ventilation
Adult
medicine.medical_specialty
HDL
high-density lipoprotein
macromolecular substances
Asymptomatic
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
Article
Internal medicine
medicine
Humans
Lymphocyte Count
Obesity
Neutrophil to lymphocyte ratio
Molecular Biology
Aged
Dyslipidemias
Retrospective Studies
business.industry
SARS-CoV-2
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
VLDL
very-low-density lipoprotein
COVID-19
Cell Biology
medicine.disease
Atherosclerosis
ICU
Intensive Care Units
Respiration
Artificial
TC
total cholesterol
Dyslipidemia
Diabetes Mellitus
Type 2
Erythrocyte Count
Hemoglobin
BMI
Body Mass Index
business
Zdroj: Blood Cells, Molecules & Diseases
ISSN: 1096-0961
1079-9796
Popis: Patients with COVID-19 can be asymptomatic or present mild to severe symptoms, leading to respiratory and cardiovascular complications and death. Type 2 diabetes mellitus (T2DM) and obesity are considered risk factors for COVID-19 poor prognosis. In parallel, COVID-19 severe patients exhibit dyslipidemia and alterations in neutrophil to lymphocyte ratio (NLR) associated with disease severity and mortality. To investigate whether such alterations are caused by the infection or results from preexisting comorbidities, this work analyzed dyslipidemia and the hemogram profile of COVID-19 patients according to the severity and compared with patients without T2DM or obesity comorbidities. Dyslipidemia, with a marked decrease in HDL levels, and increased NLR accompanied the disease severity, even in non-T2DM and non-obese patients, indicating that COVID-19 causes the observed alterations. Because decreased hemoglobin is involved in COVID-19 severity, and hemoglobin concentration is associated with metabolic diseases, the erythrogram of patients was also evaluated. We verified a drop in hemoglobin and erythrocyte number in severe patients, independently of T2DM and obesity, which may explain in part the need for artificial ventilation in severe cases. Thus, the control of such parameters (especially HDL levels, NLR, and hemoglobin concentration) could be a good strategy to prevent COVID-19 complications and death.
Databáze: OpenAIRE
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