COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study
Autor: | Morena Brazil Sant'Anna, Cristiane F.G. Lima, Ruy F.M. Viégas, Matteo C. Ebram, Sonia A. Andrade, Gisele Picolo, Rosa M.G. Celano, Louise F. Kimura |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Neutrophils
medicine.medical_treatment Comorbidity Single Center Gastroenterology Severity of Illness Index Hemoglobins Leukocyte Count Risk Factors LDL low-density lipoprotein RT-PCR real-time reverse transcription-polymerase chain reaction Hemoglobin concentration T2DM Type 2 diabetes mellitus Hypoxia COVID-19 coronavirus disease 2019 Anemia Hematology TG triglycerides Middle Aged Molecular Medicine medicine.symptom Lipoproteins HDL CVDs cardiovascular diseases Artificial ventilation Adult medicine.medical_specialty HDL high-density lipoprotein macromolecular substances Asymptomatic SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Article Internal medicine medicine Humans Lymphocyte Count Obesity Neutrophil to lymphocyte ratio Molecular Biology Aged Dyslipidemias Retrospective Studies business.industry SARS-CoV-2 Type 2 Diabetes Mellitus nutritional and metabolic diseases VLDL very-low-density lipoprotein COVID-19 Cell Biology medicine.disease Atherosclerosis ICU Intensive Care Units Respiration Artificial TC total cholesterol Dyslipidemia Diabetes Mellitus Type 2 Erythrocyte Count Hemoglobin BMI Body Mass Index business |
Zdroj: | Blood Cells, Molecules & Diseases |
ISSN: | 1096-0961 1079-9796 |
Popis: | Patients with COVID-19 can be asymptomatic or present mild to severe symptoms, leading to respiratory and cardiovascular complications and death. Type 2 diabetes mellitus (T2DM) and obesity are considered risk factors for COVID-19 poor prognosis. In parallel, COVID-19 severe patients exhibit dyslipidemia and alterations in neutrophil to lymphocyte ratio (NLR) associated with disease severity and mortality. To investigate whether such alterations are caused by the infection or results from preexisting comorbidities, this work analyzed dyslipidemia and the hemogram profile of COVID-19 patients according to the severity and compared with patients without T2DM or obesity comorbidities. Dyslipidemia, with a marked decrease in HDL levels, and increased NLR accompanied the disease severity, even in non-T2DM and non-obese patients, indicating that COVID-19 causes the observed alterations. Because decreased hemoglobin is involved in COVID-19 severity, and hemoglobin concentration is associated with metabolic diseases, the erythrogram of patients was also evaluated. We verified a drop in hemoglobin and erythrocyte number in severe patients, independently of T2DM and obesity, which may explain in part the need for artificial ventilation in severe cases. Thus, the control of such parameters (especially HDL levels, NLR, and hemoglobin concentration) could be a good strategy to prevent COVID-19 complications and death. |
Databáze: | OpenAIRE |
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