Clinical Improvements in Comorbid Gambling/Cocaine Use Disorder (GD/CUD) Patients Undergoing Repetitive Transcranial Magnetic Stimulation (rTMS)

Autor:	Luis Javier Gomez Perez, Graziella Madeo, Linda Marconi, Antonello Bonci, Luigi Gallimberti, Stefano Cardullo, Alberto Terraneo
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	medicine.medical_specialty medicine.medical_treatment lcsh:Medicine Craving behavioral disciplines and activities cocaine use disorder (CUD) 03 medical and health sciences gambling disorder (GD) 0302 clinical medicine craving repetitive transcranial magnetic stimulation (rTMS) Gambling-Symptoms Assessment Scale (G-SAS) dorsolateral prefrontal cortex (DLPFC) Intervention (counseling) Internal medicine mental disorders medicine Pathological Depression (differential diagnoses) business.industry lcsh:R General Medicine medicine.disease Comorbidity 030227 psychiatry Transcranial magnetic stimulation nervous system Cocaine use Dual diagnosis medicine.symptom business 030217 neurology & neurosurgery
Zdroj:	Journal of Clinical Medicine, Vol 8, Iss 6, p 768 (2019) Journal of Clinical Medicine; Volume 8; Issue 6; Pages: 768
ISSN:	2077-0383
Popis:	(1) Background: Pathological gambling behaviors may coexist with cocaine use disorder (CUD), underlying common pathogenic mechanisms. Repetitive transcranial magnetic stimulation (rTMS) has shown promise as a therapeutic intervention for CUD. In this case series, we evaluated the clinical effects of rTMS protocol stimulating the left dorsolateral prefrontal cortex (DLPFC) on the pattern of gambling and cocaine use. (2) Methods: Gambling severity, craving for cocaine, sleep, and other negative affect symptoms were recorded in seven patients with a diagnosis of gambling disorder (South Oaks Gambling Screen (SOGS) >5), in comorbidity with CUD, using the following scales: Gambling-Symptom Assessment Scale (G-SAS), Cocaine Craving Questionnaire (CCQ), Beck Depression Inventory-II (BDI-II), Self-rating Anxiety Scale (SAS), and Symptoms checklist-90 (SCL-90). The measures were assessed before the rTMS treatment and after 5, 30, and 60 days of treatment. Patterns of gambling and cocaine use were assessed by self-report and regular urine screens. (3) Results: Gambling severity at baseline ranged from mild to severe (mean ± Standard Error of the Mean (SEM), G-SAS score baseline: 24.42 ± 2.79). G-SAS scores significantly improved after treatment (G-SAS score Day 60: 2.66 ± 1.08). Compared to baseline, consistent improvements were significantly seen in craving for cocaine and in negative-affect symptoms. (4) Conclusions: The present findings provide unprecedent insights into the potential role of rTMS as a therapeutic intervention for reducing both gambling and cocaine use in patients with a dual diagnosis.
Databáze:	OpenAIRE
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