Histamine Neurons In The Tuberomamillary Nucleus: A Whole Center Or Distinct Subpopulations?
Autor: | Maria Beatrice Passani, Leonardo Munari, Gustavo Provensi, Patrizio Blandina |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
c-fos
Cognitive Neuroscience Cell Neuroscience (miscellaneous) H3-R antagonist Histamine H1 receptor c-Fos lcsh:RC321-571 Mini Review Article 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound GABA stress 0302 clinical medicine Developmental Neuroscience medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030304 developmental biology 0303 health sciences biology GABAA-R histamine medicine.anatomical_structure chemistry biology.protein Serotonin Histamine H3 receptor Nucleus Neuroscience 030217 neurology & neurosurgery Homeostasis Histamine |
Zdroj: | Frontiers in Systems Neuroscience, Vol 6 (2012) Frontiers in Systems Neuroscience |
ISSN: | 1662-5137 |
Popis: | Histamine axons originate from a single source, the tuberomamillary nucleus (TMN) of the posterior hypothalamus, to innervate almost all central nervous system (CNS) regions. This feature, a compact cell group with widely distributed fibers, resembles that of other amine systems, such as noradrenaline or serotonin, and is consistent with a function for histamine over a host of physiological processes, including the regulation of the sleep-wake cycle, appetite, endocrine homeostasis, body temperature, pain perception, learning, memory, and emotion. An important question is whether these diverse physiological roles are served by different histamine neuronal subpopulation. While the histamine system is generally regarded as one single functional unit that provides histamine throughout the brain, evidence is beginning to accumulate in favor of heterogeneity of histamine neurons. The aim of this review is to summarize experimental evidence demonstrating that histamine neurons are heterogeneous, organized into functionally distinct circuits, impinging on different brain regions, and displaying selective control mechanisms. This could imply independent functions of subsets of histamine neurons according to their respective origin and terminal projections. |
Databáze: | OpenAIRE |
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