Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion
| Autor: | Takanori Tsuda, Tsubasa Tani, Kojiro Dochi, Tsukasa Takahashi, Masaki Kato, Atsushi Imaizumi, Akiho Ikehata, Sho Nishikawa |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Blood Glucose Male endocrine system medicine.medical_specialty Curcumin medicine.medical_treatment Incretin Administration Oral 030209 endocrinology & metabolism Enteroendocrine cell Stimulation Biology Benzoates Cell Line Receptors G-Protein-Coupled Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Glucagon-Like Peptide 1 Internal medicine medicine Animals Insulin Secretion digestive oral and skin physiology Glucose Tolerance Test Glucagon-like peptide-1 Hypoglycemia 030104 developmental biology Endocrinology Glucose Pyrimidines chemistry Secretagogue hormones hormone substitutes and hormone antagonists Injections Intraperitoneal Food Science Biotechnology |
| Zdroj: | Molecular nutritionfood research. 61(3) |
| ISSN: | 1613-4133 |
| Popis: | cope Glucagon-like peptide-1 (GLP-1) is a type of incretin secreted from enteroendocrine L-cells. Our previous studies demonstrated that curcumin (a yellow pigment of turmeric) significantly increases the secretion of GLP-1 in enteroendocrine L cell line (GLUTag cells). However, it is not clear whether its action in vivo directly enhances GLP-1 secretion, which then leads to a reduction in blood glucose levels via the stimulation of insulin secretion. In addition, the molecular target of curcumin-induced GLP-1 secretion has not been clarified. Methods and results Glucose tolerance was significantly improved in rats after pre-administered curcumin (1.5 mg/kg) followed by intraperitoneal glucose injections via the stimulation of GLP-1 secretion and the induction of insulin secretion. In GLUTag cells, curcumin-induced GLP-1 secretion was associated with G protein-coupled receptor (GPR) 140/120. Furthermore, the glucose-lowering effect induced by curcumin was significantly reduced after the administration of a GPR40/120 antagonist in rats. Conclusion These findings demonstrate the biological function of curcumin as a GLP-1 secretagogue and the possible molecular target that mediates GLP-1 secretion. Increases in the secretion of endogenous GLP-1 induced by curcumin may allow the dosages of other diabetic medicines to be reduced and aid in the prevention of diabetes. This article is protected by copyright. All rights reserved |
| Databáze: | OpenAIRE |
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