Morphological and Biochemical Investigation of the Healing Effects of Exercise on High Fat Diet Induced Kidney and Bladder Damage

Autor: Merve AÇIKEL ELMAS, Özlem BİNGÖL ÖZAKPINAR, Meltem KOLGAZİ, Göksel ŞENER, Feriha ERCAN
Přispěvatelé: Açıkel Elmas M., Bingöl Özakpınar Ö., Kolgazi M., Şener G., Ercan F.
Rok vydání: 2022
Předmět:
kidney
Temel Tıp Bilimleri
Histoloji-Embriyoloji
Life Sciences (LIFE)
Medicine (miscellaneous)
CELL BIOLOGY
Assessment and Diagnosis
High fat diet
exercise
bladder
Sağlık Bilimleri
Temel Bilgi ve Beceriler
Genel Tıp
Fundamental Medical Sciences
Pathophysiology
Clinical Medicine (MED)
TIP
GENEL & DAHİLİ
Health Care Sciences and Services
Health Sciences
Yaşam Bilimleri
Internal Medicine
Klinik Tıp (MED)
Sağlık Bilimleri ve Hizmetleri
Aile Sağlığı
MEDICINE
GENERAL & INTERNAL
Moleküler Biyoloji ve Genetik
Dahiliye
Patofizyoloji
Klinik Tıp
Hücre Biyolojisi
Histology and Embryology
Fundamentals and Skills
Life Sciences
General Medicine
CLINICAL MEDICINE
HÜCRE BİYOLOJİSİ
Değerlendirme ve Teşhis
Tıp
MOLECULAR BIOLOGY & GENETICS
Yaşam Bilimleri (LIFE)
General Health Professions
Medicine
Tıp (çeşitli)
Family Practice
Genel Sağlık Meslekleri
Zdroj: Volume: 12, Issue: 4 817-823
Clinical and Experimental Health Sciences
ISSN: 2459-1459
Popis: Objective: The aim of this study was to evaluate the ameliorative effects of swimming training on renal and bladder damage caused by a highfat diet (HFD) using morphological and biochemical measurements. Methods: Sprague Dawley rats were fed either standard chow (CONT, 6% fat) or HFD (45% fat) for 18 weeks, these rats were divided into two subgroups at the last 6 weeks of the experiment. The exercise groups (CONT+EXC, HFD+EXC) were trained daily swimming sessions (1 h per day for 5 days/week) during the last 6 weeks. Kidney and bladder samples were prepared for light and electron microscopic examination at the end of experiment. Malondialdehyde, glutathione, interleukin-6, and tumor necrosis factor-α were measured by biochemically. Results: Regular morphology of the renal cortex and bladder mucosa was observed in the CONT and CONT +EXC groups. Degenerated renal corpuscles and proximal tubules in the kidney and degenerated urothelium with leaky tight junctions and mast cell increase in the bladder mucosa were observed in the HFD group. Ameliorated renal cortex and bladder mucosa were observed in the HFD+EXC group. In addition, malondialdehyde, glutathione, interleukin-6, and tumor necrosis factor-α levels were also consistent with the histological findings. Conclusion: HFD-induced renal and bladder damage may be related to increased oxidative damage. It was observed that the histological damage and altered oxidative stress parameters could be reversed by swimming training, and it is thought that moderate swimming exercise may play a role in regulating oxidative stress.
Databáze: OpenAIRE
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