Synergistic antitumor activity of vincristine and VP-16-213
| Autor: | Timothy M. Morgan, Thomas F. Trahey, Tony R. Long, Don V. Jackson |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Cancer Research Vincristine Ratón medicine.medical_treatment Pharmacology Toxicology Mice In vivo Antineoplastic Combined Chemotherapy Protocols medicine Animals Pharmacology (medical) Saline Etoposide Podophyllotoxin Antitumor activity Leukemia Experimental business.industry Drug Synergism Drug interaction medicine.disease Leukemia Oncology business medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 13:176-180 |
| ISSN: | 1432-0843 0344-5704 |
| DOI: | 10.1007/bf00269024 |
| Popis: | The potential interaction of the antitumor agents vincristine and VP-16-213 was investigated in vivo. DBA/2 mice were inoculated with 10(6) P388 murine leukemia cells, after which single IP injections of saline only, vincristine only, VP-16-213 only, or a combination of vincristine and VP-16-213 were administered. Long-term survival (greater than 60 days) was observed in 0/45, 1/45 (2%), 9/135 (7%), and 44/135 (33%) mice, respectively (P less than 0.001). Treatment was most effective when VP-16-213 was administered 0-72 h after vincristine. A similar trend was observed in mice bearing P1534 murine leukemia. These data demonstrate synergistic antitumor activity between vincristine and VP-16-213 in a murine model. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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