Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics

Autor: André Alves, Flávio Reis, Lígia Salgueiro, Cláudia Cavadas, Artur Figueirinha, Inês Preguiça, Carlos M. Palmeira, Sara Nunes, Ivana Jarak, Maria Manuela Pintado, Rosa Fernandes, João S. Teodoro, Rui A. Carvalho, Anabela P. Rolo, Alexandra André, Sara Silva, Patrícia Matos, Sofia D. Viana
Přispěvatelé: Veritati - Repositório Institucional da Universidade Católica Portuguesa
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Blood Glucose
Bioenergetics
medicine.medical_treatment
Blueberry Plants
Type 2 diabetes
Gut flora
Ketogenesis
Medicine
Insulin
TX341-641
Prediabetes
Nutrition and Dietetics
biology
mitochondria function
Blueberries
Lipids
Mitochondria
Fruit and Vegetable Juices
Liver
hypercaloric diet-induced prediabetes
medicine.medical_specialty
Gut microbiota
Article
Prediabetic State
Internal medicine
Diabetes mellitus
hepatic energy metabolism
Animals
hepatoprotection
Hypercaloric diet-induced prediabetes
blueberries
gut microbiota
business.industry
Nutrition. Foods and food supply
Mitochondria function
biology.organism_classification
medicine.disease
Lipid Metabolism
Gastrointestinal Microbiome
Rats
Insulin receptor
Disease Models
Animal
Endocrinology
Diabetes Mellitus
Type 2
biology.protein
Hepatic energy metabolism
Insulin Resistance
business
Energy Intake
Energy Metabolism
Hepatoprotection
Food Science
Zdroj: Nutrients, Vol 13, Iss 4192, p 4192 (2021)
Nutrients
Nutrients; Volume 13; Issue 12; Pages: 4192
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ISSN: 2072-6643
Popis: The paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effects of BJ on glucose, insulin, and lipid profiles; gut microbiota composition; intestinal barrier integrity; and metabolic endotoxemia, as well as on hepatic metabolic surrogates, including several related to mitochondria bioenergetics. BJ supplementation for 14 weeks counteracted diet-evoked metabolic deregulation, improving glucose tolerance, insulin sensitivity, and hypertriglyceridemia, along with systemic and hepatic antioxidant properties, without a significant impact on the gut microbiota composition and related mechanisms. In addition, BJ treatment effectively alleviated hepatic steatosis and mitochondrial dysfunction observed in the prediabetic animals, as suggested by the amelioration of bioenergetics parameters and key targets of inflammation, insulin signaling, ketogenesis, and fatty acids oxidation. In conclusion, the beneficial metabolic impact of BJ in prediabetes may be mainly explained by the rescue of hepatic mitochondrial bioenergetics. These findings pave the way to support the use of BJ in prediabetes to prevent diabetes and its complications.
Databáze: OpenAIRE
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