Copeptin: a new predictor for severe obstructive sleep apnea
| Autor: | Ünal Şahin, Mevlüt Karataş, Halit Çınarka, Aziz Gümüş, Medine Cumhur Cure, Asiye Yavuz, Songül Özyurt, Servet Kayhan |
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| Přispěvatelé: | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çinarka, Halit, Kayhan, Servet, Karataş, Mevlit, Yavuz, Asiye, Gümüş, Aziz, Özyurt, Songül, Cüre, Medine Cumhur, Şahin, Ünal |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pediatrics Therapeutics and Clinical Risk Management predictor Polysomnography Copeptin Internal medicine Medicine Pharmacology (medical) In patient General Pharmacology Toxicology and Pharmaceutics obstructive sleep apnea Original Research Inflammation Chemical Health and Safety medicine.diagnostic_test business.industry Hazard ratio copeptin General Medicine medicine.disease Obstructive sleep apnea Confidence interval respiratory tract diseases inflammation Cardiology Biomarker (medicine) business Safety Research Predictor Antidiuretic |
| Zdroj: | Therapeutics and Clinical Risk Management |
| ISSN: | 1176-6336 |
| Popis: | Halit Çinarka,1 Servet Kayhan,1 Mevlüt KarataÅ,1 Asiye Yavuz,1 Aziz GümüÅ,1 Songül Özyurt,1 Medine Cumhur Cüre,2 Ünal Åahin1 1Department of Chest Diseases, 2Department of Biochemistry, Recep Tayyip ErdoÄan University, Rize, Turkey Introduction: Copeptin which is the C-terminal fragment of antidiuretic hormone (ADH), is a biomarker that has been reported to be increased in various cardiovascular disorders, cerebrovascular diseases and associated with prognosis. Patients with obstructive sleep apnea syndrome (OSAS) have a tendency to develop coronary and cerebral atherosclerotic diseases. Objectives: The aim of the present study was to study copeptin levels in patients with obstructive sleep apnea and in a control group in order to determine whether copeptin could be used as a biomarker predicting the severity of OSAS and possible complications in this group. Methods: A total of 116 patients with OSAS, diagnosed by polysomnography, and 27 controls were included in the study. Blood samples were collected after overnight fasting, and copeptin levels were measured with enzyme-linked immunosorbent assay. Results: Copeptin levels were significantly higher in the OSAS group compared to control group (2,156±502; 1,845±500 pg/mL, respectively, P=0.004). Mean copeptin level of the patients having apnea-hypopnea index (AHI) ≥30 was significantly higher than that of the patients having AHI |
| Databáze: | OpenAIRE |
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