Elevation of platelet associated antibody levels in patients with chronic idiopathic thrombocytopenic purpura expressing the B8 and/or DR3 allotypes
| Autor: | James B. Bussel, Janardan P. Pandey, Irving Schulman, S. Barandun, R. Klmberly, A. Porges, Marilyn S. Pollack, Margaret W. Hilgartner |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood Platelets Adolescent Genetic Linkage Immunology Human leukocyte antigen Biochemistry HLA-B8 Antigen HLA-DR3 Antigen HLA Antigens immune system diseases hemic and lymphatic diseases Immunopathology Genetics medicine Humans Immunology and Allergy Platelet Child Autoantibodies Autoimmune disease biology Red Cell business.industry Histocompatibility Antigens Class II Autoantibody General Medicine medicine.disease Immunoglobulin M Purpura Thrombocytopenic Child Preschool Immunoglobulin G biology.protein Antibody business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | The HLA type DR3 was present in 11 of 26 patients with Chronic Idiopathic Thrombocytopenic Purpura (ITP), a significantly increased frequency (p less than 0.05). Levels of platelet associated immunoglobulin M(PAIgM) were significantly higher in the B8 and/or DR3 positive group of chronic ITP patients than in the B8 DR3 negative patients despite similar clinical outcomes. Other immunologic parameters assessed, including serum immunoglobulin levels, rate of catabolism of transfused IgG, and antibody coated autologous red cell clearances were similar for both groups. These results suggest that there is an immunobiologic abnormality associated with the B8 DR3 allotypes which may result in a predisposition not only to chronic ITP, but also to a significant increase in PAIgM. These results are in accord with studies linking autoantibody with B8 DR3. |
| Databáze: | OpenAIRE |
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