Development of galangal essential oil-based microemulsion gel for transdermal delivery of flurbiprofen: simultaneous permeability evaluation of flurbiprofen and 1,8-cineole
| Autor: | Jie Dong, Feng-Ye Wu, Feng Han, Xue-Min Zhu, Bing-Qing Yang, Jun Chen, Yun-Fei Dong, Wei Gu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Skin Absorption Flurbiprofen Pharmaceutical Science Biological Availability 02 engineering and technology Pharmacology Administration Cutaneous 030226 pharmacology & pharmacy Permeability law.invention Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Delivery Systems Pharmacokinetics law Drug Discovery medicine Oils Volatile Animals Microemulsion Essential oil Transdermal Inflammation Nonsteroidal Eucalyptol Organic Chemistry Anti-Inflammatory Agents Non-Steroidal musculoskeletal system 021001 nanoscience & nanotechnology Bioavailability Rats Disease Models Animal chemistry Permeability (electromagnetism) Area Under Curve Alpinia lipids (amino acids peptides and proteins) Emulsions 0210 nano-technology medicine.drug |
| Zdroj: | Drug development and industrial pharmacy. 46(1) |
| ISSN: | 1520-5762 |
| Popis: | Flurbiprofen (FP) is one of the most potent nonsteroidal anti-inflammatory drugs with very low bioavailability of approximately 12% following transdermal administration, compared to that after oral administration. This study aimed to deliver FP as a microemulsion (ME) gel by transdermal administration. Galangal essential oil (GEO) was extracted from Rhizoma Alpiniae Officinarum and identified by GC-MS. The most abundant constituent was determined to be 1,8-cineole (52.06%). Compared to azone, GEO was proved to exert significantly higher (p p In vivo pharmacokinetic studies revealed that the AUC0-t of FP after transdermal administration of FP-GEO-ME gel was higher by approximately 4.56-fold than that of marketed FP cataplasms. The relative bioavailability of FP and 1,8-cineole after transdermal administration compared to oral administration of FP-GEO-ME were determined to be 96.58% and 85.49%, respectively. FP-GEO-ME gel significantly inhibited carrageenan-induced hind-paw edema and decreased PGE2 levels in rat serum. GEO-ME gel also exhibited significant anti-inflammatory effects at 2 h after the therapy (p |
| Databáze: | OpenAIRE |
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