Combination of Zizyphus jujuba and Green Tea Extracts Exerts Excellent Cytotoxic Activity in HepG2 Cells via Reducing the Expression of APRIL
| Autor: | Isao Matsui-Yuasa, Tadayoshi Hasuma, Xuedan Huang, Akiko Kojima-Yuasa, Shenghui Xu, David Opare Kennedy |
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| Rok vydání: | 2009 |
| Předmět: |
Carcinoma
Hepatocellular Cell Survival Tumor Necrosis Factor Ligand Superfamily Member 13 Gene Expression Pharmacology Camellia sinensis law.invention law Cell Line Tumor Antineoplastic Combined Chemotherapy Protocols Botany medicine Animals Humans Cytotoxic T cell Cytotoxicity Tea Plant Extracts Chemistry Cell Cycle Liver Neoplasms Ziziphus General Medicine Cell cycle medicine.disease Antineoplastic Agents Phytogenic In vitro Rats Complementary and alternative medicine Cell culture Hepatocellular carcinoma Phytotherapy Liver cancer |
| Zdroj: | The American Journal of Chinese Medicine. 37:169-179 |
| ISSN: | 1793-6853 0192-415X |
| DOI: | 10.1142/s0192415x09006758 |
| Popis: | Hepatocellular carcinoma is a type of tumor highly resistant to available chemotherapeutic agents. The treatment of hepatocellular carcinoma remains a challenge that needs new approaches in the future. In a previous study, we demonstrated that the chloroform fraction (CHCl3-F) from Z. jujuba has anticancer activity in human liver cancer cells (HepG2), and that combining CHCl3-F with green tea extracts (GTE) results in enhanced effects of anticancer activity in the cells. To further understand the mechanism of the anticancer activity of combining CHCl3-F and GTE in HepG2 cells, we investigated whether the addition of a mixture of CHCl3-F and GTE would affect the expression of APRIL (a proliferation-inducing ligand), which was expressed in HepG2 cells from 4 hours of incubation in vitro. We have shown that CHCl3-F and GTE enhanced anti-cancer activity by reducing the expression of APRIL. We speculate that the CHCl3-F and GTE mixture might provide a lead to a new drug design to treat hepatocellular carcinoma in the future. |
| Databáze: | OpenAIRE |
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