Cardiovascular effects of treadmill exercise in physiological and pathological preclinical settings
| Autor: | Fabio Magliulo, Cinzia Perrino, Laura Scudiero, Federica Ilardi, Gianluigi Pironti, Giovanni Esposito, Mario De Laurentis, Anna Franzone, Gabriele G. Schiattarella, Giuseppe Gargiulo, Giuseppe Carotenuto |
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| Přispěvatelé: | Perrino, Cinzia, Gargiulo, G., Pironti, G., Franzone, A., Scudiero, L., De Laurentis, M., Magliulo, F., Ilardi, F., Carotenuto, G., Schiattarella, Gg, Esposito, Giovanni |
| Rok vydání: | 2011 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Physiology Cardiomegaly Treadmill exercise Disease Bioinformatics Muscle hypertrophy Cardiovascular Physiological Phenomena Mice Physical Conditioning Animal Physiology (medical) Internal medicine medicine Animals Humans Pathological Mice Knockout business.industry Skeletal muscle Adaptation Physiological Mice Inbred C57BL Disease Models Animal Endocrinology medicine.anatomical_structure Cardiovascular Diseases Circulatory system Exercise Test Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 300:H1983-H1989 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.00784.2010 |
| Popis: | Exercise adaptations result from a coordinated response of multiple organ systems, including cardiovascular, pulmonary, endocrine-metabolic, immunologic, and skeletal muscle. Among these, the cardiovascular system is the most directly affected by exercise, and it is responsible for many of the important acute changes occurring during physical training. In recent years, the development of animal models of pathological or physiological cardiac overload has allowed researchers to precisely analyze the complex cardiovascular responses to stress in genetically altered murine models of human cardiovascular disease. The intensity-controlled treadmill exercise represents a well-characterized model of physiological cardiac hypertrophy because of its ability to mimic the typical responses to exercise in humans. In this review, we describe cardiovascular adaptations to treadmill exercise in mice and the most important parameters that can be used to quantify such modifications. Moreover, we discuss how treadmill exercise can be used to perform physiological testing in mouse models of disease and to enlighten the role of specific signaling pathways on cardiac function. |
| Databáze: | OpenAIRE |
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