Plant protein-based hydrophobic fine and ultrafine carrier particles in drug delivery systems
| Autor: | Fazel Baniasadi, Michael R. Hamblin, Mahdi Karimi, Maryam Sharifi Aghdam, Parham Sahandi Zangabad, Hamed Mirshekari, S M Moosavi Basri, Hedieh Malekzad |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug Biocompatibility media_common.quotation_subject Zein 02 engineering and technology Applied Microbiology and Biotechnology Gliadin Article 03 medical and health sciences Mice Drug Delivery Systems Legumin Nanobiotechnology Animals Humans Particle Size media_common Plant Proteins Active ingredient Chemistry food and beverages General Medicine 021001 nanoscience & nanotechnology Recombinant Proteins 030104 developmental biology Nanomedicine Biochemistry Plant protein Drug delivery 0210 nano-technology Hydrophobic and Hydrophilic Interactions Biotechnology |
| Zdroj: | Critical reviews in biotechnology. 38(1) |
| ISSN: | 1549-7801 |
| Popis: | For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes. Zein is a water-insoluble protein from maize; Gliadin is a 70% alcohol-soluble protein from wheat and corn; legumin is a casein-like protein from leguminous seeds such as peas; lectins are glycoproteins naturally occurring in many plants that recognize specific carbohydrate residues. NPs formed from these proteins show good biocompatibility, possess the ability to enhance solubility, and provide sustained release of drugs and reduce their toxicity and side effects. The effects of preparation methods on the size and loading capacity of these NPs are also described in this review. |
| Databáze: | OpenAIRE |
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