Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database
| Autor: | Yu Ning Wang, Tao Chen, Dong Xie, Mu Li, Chang Chen, Ping Yang, Wang Long, Rui Mao, Chen Yang Dai |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Gerontology Male medicine.medical_specialty Multivariate analysis Subgroup analysis 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology medicine Humans Survival analysis Aged Marital Status Proportional hazards model business.industry Hazard ratio tracheal cancer socio-economics Middle Aged Prognosis Survival Analysis Confidence interval SEER 030104 developmental biology Oncology 030220 oncology & carcinogenesis Marital status Female Tracheal Neoplasms business Research Paper SEER Program |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Mu Li 1 , Chen-Yang Dai 1 , Yu-Ning Wang 2 , Tao Chen 1 , Long Wang 1 , Ping Yang 3 , Dong Xie 1 , Rui Mao 1 , Chang Chen 1 1 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China 2 Deloitte and Touche Financial Advisory Services Limited, Shanghai, People’s Republic of China 3 Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Correspondence to: Chang Chen, email: changchenc@hotmail.com Keywords: tracheal cancer, marital status, socio-economics, SEER, survival analysis Received: June 07, 2016 Accepted: October 12, 2016 Published: October 21, 2016 ABSTRACT Background: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. Results: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.64–0.95, p = 0.015) and TCSS (HR = 0.70, 95% CI 0.54–0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95% CI 0.53–0.93, p = 0.015). Methods: We extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t -test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages. Conclusions: Marital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors. |
| Databáze: | OpenAIRE |
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