Body mass index and its association with COVID-19 clinical outcomes: Findings from the Philippine CORONA study

Autor: Adrian I. Espiritu, Nikolai Gil D. Reyes, Carl Froilan D. Leochico, Marie Charmaine C. Sy, Emilio Q. Villanueva III, Veeda Michelle M. Anlacan, Roland Dominic G. Jamora
Rok vydání: 2022
Předmět:
Zdroj: Clinical Nutrition ESPEN. 49:402-410
ISSN: 2405-4577
DOI: 10.1016/j.clnesp.2022.03.013
Popis: To explore the association between body mass index (BMI) and adverse outcomes in a large cohort of patients with coronavirus disease 2019 (COVID-19).This is a secondary analysis of a 37-site, nationwide, multicenter, retrospective cohort study that investigated the clinical and neurological outcomes of adult patients with confirmed COVID-19 admitted from February to December 15, 2020.We analyzed 4,463 patients with BMI and outcome data. A total of 790 (17.7%) and 710 (15.9%) had the primary outcome of in-hospital mortality and need for invasive mechanical ventilation (IMV), respectively. There was no significant association between WHO BMI groups and these outcomes. Using Asia-Pacific cutoffs showed a significant association between obesity and in-hospital mortality risk (P = 0.012). Being underweight was an independent predictor of prolonged IMV requirement regardless of BMI criteria used (P0.01). Obesity correlated with the need for intensive care unit admission using Asia-Pacific cutoffs (P = 0.029). There was a significant association between any BMI abnormality and odds of severe/critical COVID-19 (P0.05). Obese patients with concomitant acute neurological presentation/diagnosis during their COVID-19 admission were shown to have lower odds of neurologic recovery (P0.05).We found BMI abnormalities to be associated with several adverse clinical and neurologic outcomes, although such associations may be more evident with the use of race-specific BMI criteria.
Databáze: OpenAIRE
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