Predictors of vaginal delivery after cervical ripening using a synthetic osmotic dilator
| Autor: | Gary D.V. Hankins, Lukáš Hruban, George R. Saade, Antonio F. Saad, Janesh K. Gupta |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Polymers Bishop score Gestational Age Logistic regression Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Humans Medicine Labor Induced 030212 general & internal medicine Proportional Hazards Models 030219 obstetrics & reproductive medicine Cesarean Section Proportional hazards model business.industry Obstetrics Vaginal delivery Obstetrics and Gynecology Gestational age Ripening Delivery Obstetric Confidence interval 3. Good health Reproductive Medicine Dilator Female business Cervical Ripening |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 246:160-164 |
| ISSN: | 0301-2115 |
| Popis: | To evaluate the determinants of vaginal delivery and safety in women undergoing cervical ripening with a synthetic osmotic dilator (Dilapan-S) prior to induction of labor.We conducted a secondary analysis of an international multicenter prospective observational study of Dilapan-S for cervical ripening in pregnancies greater than 32 weeks. Data were obtained in a standardized fashion and entered into a centralized electronic data capture system. The association between Bishop score and vaginal delivery was further evaluated with a multivariate receiver-operating characteristic (ROC) curve analysis. A Wilcoxon rank test and multivariable logistic regression were used for statistical analysis (significance: P.05).Between May 2015 and July 2016, 444 pregnant women were included. Three hundred ten (70 %) delivered vaginally. Compared to patients who underwent cesarean delivery, those who delivered vaginally were more likely to have a history of prior vaginal delivery. Vaginal delivery rates were significantly correlated with Bishop scores of pre and post Dilapan-S and difference. After adjusting for age, BMI, number of dilators, cervical ripening time, and gestational age, both prior vaginal delivery and post-Dilapan-S Bishop scores were strong predictors of vaginal delivery (estimate coefficient: 0.1275 ± 0.03 P = .0002; 0.049 ± 0.01 P = .0001; respectively). Aggregate ROC accounting for these variables further supported these findings (AUC = 0.734). The lower confidence interval limit of vaginal delivery rates was above 50 % when post-Dilapan-S Bishop scores were ≥ 5. Cox regression analyses demonstrated that the duration of labor was significant shorter in women that had vaginal delivery.Bishop scores after cervical ripening with Dilapan-S are good predictors of vaginal delivery. Bishop scores5 post Dilapan-S may warrant further cervical ripening. Further level 1 trials are needed to compare osmotic dilators to other ripening methods. |
| Databáze: | OpenAIRE |
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