Combined epidural morphine and bupivacaine in the treatment of lumbosacral radicular neuropathic pain: a noncontrolled prospective study
| Autor: | Laura Ravaioli, Matteo Zanella, Marco La Grua, Simone Vigneri, Gianfranco Sindaco, Gilberto Pari, Valentina Paci |
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| Přispěvatelé: | Vigneri, S., Sindaco, G., La Grua, M., Zanella, M., Ravaioli, L., Paci, V., Pari, G. |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Chronic pain Opioid Neuropathic pain Epidural morphine 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology medicine Journal of Pain Research Prospective cohort study Bupivacaine Epidural Opioids Anesthesiology and Pain Medicine Original Research lcsh:R5-920 business.industry opioids medicine.disease Epidural space Surgery Epidural - Opioids - Bupivacaine - Neuropathic pain - Chronic pain medicine.anatomical_structure Anesthesia Morphine lcsh:Medicine (General) business 030217 neurology & neurosurgery Lumbosacral joint medicine.drug |
| Zdroj: | Journal of Pain Research, Vol Volume 9, Pp 1081-1087 (2016) Journal of Pain Research |
| ISSN: | 1178-7090 |
| Popis: | Simone Vigneri,1,2 Gianfranco Sindaco,2 Marco La Grua,2 Matteo Zanella,2 Laura Ravaioli,2 Valentina Paci,2 Gilberto Pari2 1Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, 2Advanced Algology Research and Pain Medicine Unit, Santa Maria Maddalena Hospital, Occhiobello, RO, Italy Objective: The aim of this study was to investigate the therapeutic effectiveness of epidural morphine and bupivacaine in patients with chronic lumbosacral radicular neuropathic pain after the cessation of treatment.Methods: Twenty-two patients with chronic lumbosacral pain with neuropathic features were enrolled. An indwelling catheter was placed into the epidural space, and each patient received an epidural injection of morphine chlorhydrate and bupivacaine up to three times a day. The medication was administered for 4 weeks. The pain intensity score on a 0–10 numeric rating scale (NRS), the total pain rating index rank (PRIr-T), and its coefficients were evaluated before treatment and 1 month after catheter removal. P-value 30% in NRS) was reached and maintained in half of the patients at follow-up.Conclusion: Combined epidural morphine and bupivacaine seems to be effective in the treatment of neuropathic pain. Keywords: epidural, opioids, bupivacaine, neuropathic pain, chronic pain |
| Databáze: | OpenAIRE |
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