Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study
| Autor: | Augustin Latourte, Fernando Perez-Ruiz, Thomas Bardin, Aïcha Soumaré, Pascal Richette, Stéphanie Debette |
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| Přispěvatelé: | Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2017 |
| Předmět: |
Male
Aging medicine.medical_specialty Gout Immunology Sensitivity and Specificity General Biochemistry Genetics and Molecular Biology Cohort Studies 03 medical and health sciences 0302 clinical medicine Blood serum Rheumatology Risk Factors Internal medicine Epidemiology Humans Immunology and Allergy Medicine Dementia Longitudinal Studies Psychiatry Aged Aged 80 and over 030203 arthritis & rheumatology business.industry Incidence Incidence (epidemiology) Brain medicine.disease Magnetic Resonance Imaging Uric Acid 3. Good health VINTAGE Ageing Cohort Female [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie France business Biomarkers 030217 neurology & neurosurgery Follow-Up Studies Cohort study |
| Zdroj: | Annals of the Rheumatic Diseases Annals of the Rheumatic Diseases, BMJ Publishing Group, 2018, 77 (3), pp.328-335. ⟨10.1136/annrheumdis-2016-210767⟩ |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | ObjectivesIn patients with gout, maintaining too low serum uric acid (SUA) level with urate-lowering therapy is a concern because uric acid is thought to be neuroprotective. However, the relation between SUA and dementia remains debated. This study aimed to investigate the impact of SUA level on the incidence of dementia.MethodsWe assessed the longitudinal association between SUA level and incident dementia (Diagnostic and Statistical Manual of Mental Disorders Version IV (DSM-IV) criteria) in a large cohort of healthy older people from the community (Three-City Dijon cohort). Additionally, we investigated the relation between SUA level and MRI markers of brain ageing (white matter hyperintensity volume (WMHV), lacunes and hippocampal volume).ResultsThe study sample comprised 1598 people (mean (SD) age 72.4(4.1) years, 38.3% male). During the 13,357 person-years of follow-up (median duration: 10.1 years), dementia developed in 110 participants (crude incidence rate: 8.2/1000 person-years). After multiple adjustments, the multivariate HR with the highest (≥75th percentile) versus lowest SUA level was 1.79 (95% CI 1.17 to 2.73; p=0.007). The association was stronger with vascular or mixed dementia (HR=3.66 (95% CI 1.29 to 10.41), p=0.015) than Alzheimer’s disease (HR=1.55 (95% CI 0.92 to 2.61), p=0.10). There was a non-significant trend towards an association between high SUA level and extensive WMHV (p=0.10), a biomarker of small vessel disease, but not hippocampal volume (p=0.94) or lacunes (p=0.86). The association between SUA level and vascular or mixed dementia might be affected by interim strokes.ConclusionsRisk of dementia, especially vascular or mixed dementia, may be increased with high SUA levels in elderly people. |
| Databáze: | OpenAIRE |
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