5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression
| Autor: | Robert Bonwetsch, Maria T. Toczek, Wayne C. Drevets, Giampiero Giovacchini, Anto Bagic, William H. Theodore, David A. Luckenbaugh, Gregor Hasler |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent Electroencephalography behavioral disciplines and activities Functional Laterality Piperazines Article Temporal lobe Central nervous system disease Epilepsy Cyclohexanes Internal medicine mental disorders medicine Humans Ictal Biological Psychiatry Depression (differential diagnoses) Depressive Disorder Major medicine.diagnostic_test Middle Aged medicine.disease Magnetic Resonance Imaging Comorbidity Epilepsy Temporal Lobe nervous system Positron-Emission Tomography Receptor Serotonin 5-HT1A Major depressive disorder Female Radiopharmaceuticals Psychology Neuroscience |
| Zdroj: | Biological Psychiatry. 62:1258-1264 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2007.02.015 |
| Popis: | Background Major depressive disorder (MDD) is the most common comorbid psychiatric condition associated with temporal lobe epilepsy (TLE). Preclinical and clinical studies suggest that 5-HT 1A receptors play a role in the pathophysiology of both TLE and MDD. There is preliminary evidence for an association between decreased 5-HT 1A receptor binding in limbic brain areas and affective symptoms in TLE patients. The objective of this study was to compare 5-HT 1A receptor binding between TLE patients with and without MDD. For the first time, 5-HT 1A receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews. Methods Thirty-seven epilepsy patients with temporal lobe foci confirmed by ictal video-electroencephalogram (EEG) monitoring were recruited from the Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke. We performed interictal positron emission tomography scanning, with [ 18 F]FCWAY, a fluorinated derivative of WAY100635, on a GE Medical Systems (Waukesha, Wisconsin) Advance scanner with continuous EEG monitoring. The 5-HT 1A receptor binding was estimated by partial volume-corrected [ 18 F]FCWAY V/f 1 values. Results In addition to decreased 5-HT 1A receptor binding in the epileptic focus itself, comorbid MDD was associated with a significantly more pronounced reduction in 5-HT 1A receptor binding in TLE patients, extending into non-lesional limbic brain areas outside the epileptic focus. Focus side and the presence of mesial temporal sclerosis were not associated with the presence of comorbid depression. Conclusions Reductions in 5-HT 1A receptor binding might help elucidate the neurobiological mechanisms underlying the TLE–MDD comorbidity. |
| Databáze: | OpenAIRE |
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