CSC MARKERS IN OSCC AND THEIR ASSOCIATION WITH CLINICAL FACTORS

Autor:	Go Ohe, Takayuki Nakagawa, Kazuya Akita, Tetsuya Tamatani, Natsumi Takamaru, Youji Miyamoto
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine Cancer Research Metastasis 03 medical and health sciences 0302 clinical medicine Cancer stem cell Biopsy medicine cluster of differentiation 24 aldehyde dehydrogenase 1 cluster of differentiation 44 Survival rate cluster of differentiation 44 variant 9 Cluster of differentiation biology medicine.diagnostic_test B lymphoma Mo‑MLV insertion region 1 homolog business.industry ATP‑binding cassette sub‑family G member 2 CD44 Cancer Articles oral cancer medicine.disease Lymphoma 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research biology.protein business
Zdroj:	Oncology Letters. 16(1):1133-1140
ISSN:	1792-1074
Popis:	Cancer stem cells (CSCs) exhibit self-replication, self-differentiation, drug resistance and immune evasion activities. In recent years CSCs have become increasingly important for the treatment of malignant tumors. CSCs express specific markers, including cluster of differentiation (CD)44, CD44 variant 9 (CD44v9), ATP-binding cassette sub-family G member 2 (ABCG2), CD24, B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) and aldehyde dehydrogenase 1 (ALDH1). However, the prognostic value of their expression in patients with oral squamous cell carcinoma (OSCC) are not well known. The present study evaluated these markers in stage I and II patients with OSCC and examined the association between T classification, histological differentiation, classification of invasion mode, lymph node metastasis and disease-free survival rate. Tissue specimens were obtained from 70 patients with stage I or II OSCC following either surgery or biopsy. Immunohistochemistry was performed and positive staining was defiend as 10% positive cells. CD44 and CD44v9 expressions were strongly detected in all OSCC tissues compared with normal epithelial cells. A total of 22 (31.4%) cases expressed ABCG2 and there was a significant association between ABCG2 expression and invasion. A total of 41 cases (59.0%) expressed CD24 and there was a significant association between CD24 expression and invasion. A total of 33 cases (47.1%) expressed BMI-1 and there was a significant association between BMI-1 expression and the disease-free survival rate. A total of 18 cases (25.7%) expressed ALDH1. Although there was no association between ALDH1 expression and T classification, there were significant associations between ALDH1 expression and histological differentiation, invasion mode, metastasis and the disease-free survival rate. Multivariate analysis revealed that ALDH1 expression was the only prognostic factor for disease-free survival rate. The results of the present study suggest that the positivity of ALDH1 detected in patients with OSCC correlates with the number of cells undergoing epithelial mesenchymal transition and metastasis. These findings indicated that the expression of ALDH1 may be an effective prognostic marker indicating the survival of patients with stage I and II OSCC.
Databáze:	OpenAIRE
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