SARS‐CoV‐2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein
| Autor: | Yury K. Kavalionak, Siarhei A. Dabravolski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Protein Conformation Short Communication Short Communications Genome Viral medicine.disease_cause SARS‐CoV‐2 Host Specificity 03 medical and health sciences Structure-Activity Relationship 0302 clinical medicine Phylogenetics COVID‐19 Virology medicine Animals Humans Pipistrellus 030212 general & internal medicine spike glycoprotein Phylogeny Coronavirus Genetics biology Phylogenetic tree Whole Genome Sequencing SARS-CoV-2 Intermediate host Outbreak COVID-19 Genomics biology.organism_classification betacoronavirus Viral Tropism Infectious Diseases Tylonycteris pachypus Spike Glycoprotein Coronavirus 030211 gastroenterology & hepatology Betacoronavirus |
| Zdroj: | Journal of Medical Virology |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | To investigate the evolutionary history of the current pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a total of 137 genomes of coronavirus strains with release dates between January 2019 and 25 March 2020, were analyzed. To investigate the potential intermediate host of the SARS‐CoV‐2, we analyzed spike glycoprotein sequences from different animals, with particular emphasis on bats. We performed phylogenetic analysis and structural reconstruction of the spike glycoproteins with subsequent alignment and comparison. Our phylogenetic results revealed that SARS‐CoV‐2 was more similar to the bats' betacoronavirus isolates: HKU5‐related from Pipistrellus abramus and HKU4‐related from Tylonycteris pachypus. We also identified a yak betacoronavirus strain, YAK/HY24/CH/2017, as the closest match in the comparison of the structural models of spike glycoproteins. Interestingly, a set of unique features has been described for this particular strain of the yak betacoronavirus. Therefore, our results suggest that the human SARS‐CoV‐2, responsible for the current outbreak of COVID‐19, could also come from yak as an intermediate host. Highlights Spike glycoprotein sequences analysis of the set of recent corona viruses compared to SARS‐CoV‐2.Phylogenetic and structural analysis of the spike glycoproteins sequences.Phylogenetic study shows close clustering of SARS‐CoV‐2 and bats' coronavirus sequences.Structures comparison suggests yak (Bos grunniens) as an intermediate host for the SARS‐CoV‐2.The N‐terminal domain binds to carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) in mouse hepatitis coronavirus, and binds sugar in porcine transmissible gastroenteritis virus. |
| Databáze: | OpenAIRE |
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