Do 1,8-naphthyridine sulfonamides possess an inhibitory action against Tet(K) and MsrA efflux pumps in multiresistant Staphylococcus aureus strains?
| Autor: | Alexandre Magno Rodrigues Teixeira, Pedro Silvino Pereira, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Teresinha Gonçalves da Silva, Sandro Lucio Mireski, Henrique Douglas Melo Coutinho, Luiz Everson da Silva, Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Ricardo Andrade Rebelo, Maria Isabel Lacowicz Krautler, Saulo R. Tintino, Cícera Datiane de Morais Oliveira-Tintino, Irwin Rose Alencar de Menezes, Michele Caroline Nasato |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Staphylococcus aureus medicine.drug_class Stereochemistry 030106 microbiology Antibiotics Microbial Sensitivity Tests medicine.disease_cause Microbiology 03 medical and health sciences chemistry.chemical_compound Bacterial Proteins Ethidium medicine Naphthyridines Antibacterial agent Sulfonamides Sulfonamide (medicine) Anti-Bacterial Agents 030104 developmental biology Infectious Diseases chemistry Efflux Ethidium bromide Antibacterial activity MSRA medicine.drug |
| Zdroj: | Microbial Pathogenesis. 147:104268 |
| ISSN: | 0882-4010 |
| Popis: | Naphthyridines represent a class of heterocyclic compounds formed by two condensed aromatic rings. This study aimed to evaluate the antibacterial activity and in vitro inhibition of efflux resistance mechanisms of a series of 1,8-naphthyridine sulfonamides against strains carrying Tet(K) and MsrA efflux pumps. The efflux pump inhibitory capacity was evaluated by analyzing synergistic effects between 1,8-naphthyridine sulfonamides and standard antibiotics, as well as ethidium bromide. The following 1,8-naphthyridines were used: 4-methyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 1); 2,5-Dichloro-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 2); 2,3,4-trifluoro-N-(5-chloro-1,8-naphthyridin-2-yl)benzenesulfonamide (Naph 7); 3-trifluoromethyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 9). The 1,8-naphthyridine sulfonamide derivatives possessed a potential Tet(K) and MsrA efflux pump inhibitory action. |
| Databáze: | OpenAIRE |
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