Evaluation of Intraarterial Thrombolysis in Treatment of Cosmetic Facial Filler-Related Ophthalmic Artery Occlusion
| Autor: | Qiang Dai, Minliang Chen, Lixia Zhang, Yunchao Zhou, Liming Liang, Linying Lai, You-tao Yu, Xinyue Bai, Wei-qiang Tang, Guiwen Zhou |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity Intraarterial thrombolysis Injections Subcutaneous Embolism Visual Acuity Hyaluronoglucosaminidase Cosmetic Techniques 030230 surgery Blindness Eye 03 medical and health sciences chemistry.chemical_compound Ophthalmic Artery 0302 clinical medicine medicine.artery Dermal Fillers Occlusion Hyaluronic acid medicine Humans Thrombolytic Therapy Hyaluronic Acid Retrospective Studies medicine.diagnostic_test business.industry Angiography Digital Subtraction medicine.disease Urokinase-Type Plasminogen Activator Surgery Treatment Outcome chemistry Injections Intra-Arterial 030220 oncology & carcinogenesis Ophthalmic artery Angiography Drug Therapy Combination Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Plastic and reconstructive surgery. 145(1) |
| ISSN: | 1529-4242 |
| Popis: | With an increase in recent years in the number of people receiving cosmetic facial injection treatments of hyaluronic acid, the incidence of hyaluronic acid embolism has also increased commensurately. Hyaluronic acid embolism leads to serious complications, including blindness, eye and eyelid movement disorders, skin necrosis, and cerebral embolism. However, there is a lack of robust clinical evidence regarding the benefits of treatment for hyaluronic acid embolism by intraarterial thrombolysis therapy.This study included 24 patients with a decrease in visual acuity and other complications induced by facial hyaluronic acid injection. Patients underwent emergency intraarterial thrombolysis therapy by injection of hyaluronidase (500 to 1500 units) alone or hyaluronidase (750 to 1500 units) combined with urokinase (100,000 to 250,000 units), followed in both cases by a general symptomatic treatment and nutritional therapy.Ten (42 percent) of 24 patients ultimately had improvements to visual acuity, even when the clinical application of the thrombolytic treatments had passed the recommended window for optimal treatment. In all cases, patients' facial skin necrosis was restored to nearly normal appearance. In addition, the authors found that hyaluronidase combined with urokinase was a more effective therapy than hyaluronidase alone.The authors' results indicate that intraarterial thrombolysis therapy is beneficial to patients suffering from blindness induced by hyaluronic acid embolism. The therapy was shown to be worthy of clinical application because it alleviated the impairment to patients' vision and was also beneficial in the recovery from other serious complications, including eye movement disorder, eye edema, headaches, and skin necrosis.Therapeutic, IV. |
| Databáze: | OpenAIRE |
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