Cutaneous Mastocytosis With Predominant Infiltration of Promastocytes
| Autor: | Angela Hernández-Martín, Almudena Matito, Nicole Knöpfel, Antonio Torrelo, Irene Latour, Lucero Noguera-Morel, Iván Álvarez-Twose, Isabel Colmenero |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pathology medicine.medical_specialty Round cells Mastocytosis Cutaneous Adolescent Dermatology Disease Aggressive disease Pathology and Forensic Medicine Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Mast Cells Child Malignant phenotype Cell Nucleus Cutaneous Mastocytosis business.industry Clinical course General Medicine medicine.disease Biological significance Child Preschool Female business Infiltration (medical) |
| Zdroj: | The American Journal of Dermatopathology. 41:296-299 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0000000000001246 |
| Popis: | Mastocytosis is a heterogeneous group of disorders with a variable clinical course, ranging from indolent disease with normal life expectancy to highly aggressive disease. In the skin, mast cells may show a spindle-shape appearance or appear as round cells with wide, polygonal cytoplasm. In this study, we present a case series of 4 patients with cutaneous childhood-onset mastocytosis in whom skin mast cells showed striking nuclear pleomorphism with bilobed and multilobed nuclei. Such finding does not seem to represent a malignant phenotype of the disease in the skin, although the true biological significance and the potential prognostic impact remain to be determined. |
| Databáze: | OpenAIRE |
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