Total Synthesis of Sekothrixide Strategically Utilizing Regioselective Coupling of TMS-Protected Epoxy sec-Alcohol with Gilman Reagent
| Autor: | Shinji Nagumo, Masaaki Miyashita, Megumi Mizukami, Daisuke Katsumi, Naoki Terayama, Kazuki Nakasone, Eiko Yasui |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Coupling
Gilman reagent 010405 organic chemistry Organic Chemistry Total synthesis Regioselectivity Alcohol Epoxy 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Yield (chemistry) visual_art Sekothrixide visual_art.visual_art_medium |
| Zdroj: | The Journal of organic chemistry. 84(3) |
| ISSN: | 1520-6904 |
| Popis: | A new efficient synthesis of sekothrixide was established on the basis of our developed regioselective coupling of epoxy sec-alcohol with Gilman reagent guided by a TMS group. The new synthetic route allowed an overall yield of 6.3% (26 steps) from optically active 3-silyloxy-2-methylaldehyde. |
| Databáze: | OpenAIRE |
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