Machine Classification of Methylomes in Cancer
| Autor: | Charles E. Massie, Sendera M, Rebecca C. Fitzgerald, Sriganesh Jammula, Newsham I, Shamith A. Samarajiwa |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Methylation Computational biology Disease Biology medicine.disease_cause 3. Good health 03 medical and health sciences 0302 clinical medicine Immune system 030220 oncology & carcinogenesis DNA methylation medicine Epigenetics Carcinogenesis Gene 030304 developmental biology Epigenomics |
| DOI: | 10.1101/2020.04.04.025155 |
| Popis: | Cancer remains a leading cause of morbidity and mortality worldwide. Its evolutionary nature and resultant complex interactions with the tumour micro-environment and the host immune system engender heterogeneity, make developing interventions difficult. Usually detected at the advanced stages of disease, metastatic cancer accounts for 90% of cancer-associated deaths. Therefore early detection of cancer, combined with current therapies, would have a significant impact on survival and treatment of this insidious disease. Epigenetic changes such as DNA methylation are some of the early events in carcinogenesis. Here, we report on a machine learning model that can classify 13 types of cancer as well as non-cancer tissue samples using only DNA methylome data, with an accuracy of 98.2%. We utilise the features identified by this model to develop a robust deep neural network that can generalise to independent data sets. We also demonstrate that the methylation associated genomic loci detected by the classifier are associated with genes involved in cancer, providing insights into the epigenomic regulation of carcinogenesis. |
| Databáze: | OpenAIRE |
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