Chemical composition and ' in vitro ' anti-inflammatory activity of Vitis vinifera L. (var. Sangiovese) tendrils extract
| Autor: | M. José Jara-Palacios, Silvia Carloni, Francesco Prattichizzo, Alexander Rudov, Daniele Fraternale, Elisa Giacomini, Giancarlo Verardo, Fabiola Olivieri, Catia Azzolini, Donata Ricci, Maria Cristina Albertini, Belén Gordillo |
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| Přispěvatelé: | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Vitis vinifera tendrils MiR-126 Lipopolysaccharide medicine.drug_class Medicine (miscellaneous) Biology Pharmacology Peripheral blood mononuclear cell Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound Anti-inflammatory activity medicine Tendril MiR-146a MIRAKIL Food Science Nutrition and Dietetics TX341-641 Endothelial dysfunction Nutrition. Foods and food supply Monocyte miR-126 medicine.disease In vitro Endothelial stem cell miR-146a 030104 developmental biology medicine.anatomical_structure chemistry Biochemistry |
| Zdroj: | Journal of Functional Foods, Vol 20, Iss, Pp 291-302 (2016) idUS. Depósito de Investigación de la Universidad de Sevilla instname |
| Popis: | Grapevine ( Vitis vinifera L.) is currently used for wine production, herbal medicine and food supplements. In this study we investigated the phenolic composition of grape tendril extract (TVV), because these compounds are prob ably r esponsible for the observed biological effects of TVV. We performed our investigation on cells implicated in the inflammatory process and in vascular damage, such as monocyte (U937) and senescent endothelial (HUVEC) cells. We analysed changes in microRNA (miRNA) expression during a pro-inflammatory condition in LPS (lipopolysaccharide) stimulated cells. MiR-126, defined as angiomiR for its ability in the maintenance of endothelial cell functions, and miR-146a, defined as inflamma-miR, for its ability to down-modulate (NF-kB nuclear factor-kB) pro-inflammatory pathway, were analysed along with their targets.TVV extract (40 g/mL) was able to prevent the LPS stimu- lus and may play an important role in the prevention of endothelial dysfunction when the accumulation of senescent endothelial cells occurs. |
| Databáze: | OpenAIRE |
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