Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Autor:	Jun Shao, Wen-Jie Zhou, Yu-Han Meng, Hui-Li Yang, Da-Jin Li, Ming-Qing Li, Chun-Jie Gu
Rok vydání:	2018
Předmět:	0301 basic medicine medicine.medical_specialty Abortion Habitual Immunology Endometriosis Inflammation medicine.disease_cause Melatonin Pathogenesis 03 medical and health sciences Pineal gland 0302 clinical medicine Immune system Internal medicine medicine Immunology and Allergy Animals Humans 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Immune dysregulation Free radical scavenger Polycystic ovary Abortion Spontaneous 030104 developmental biology Endocrinology medicine.anatomical_structure Reproductive Medicine Female medicine.symptom business hormones hormone substitutes and hormone antagonists medicine.drug Polycystic Ovary Syndrome
Zdroj:	American journal of reproductive immunology (New York, N.Y. : 1989). 80(1)
ISSN:	1600-0897
Popis:	Melatonin is a neurohormone synthesized from the aromatic amino acid tryptophan mainly by the pineal gland of mammals. Melatonin acts as a broad-spectrum antioxidant, powerful free radical scavenger, anti-inflammatory agent, anticarcinogenic factor, sleep inducer and regulator of the circadian rhythm, and potential immunoregulator. Melatonin and reproductive system are interrelated under both physiological and pathological conditions. Oxidative stress, inflammation, and immune dysregulation are associated with the pathogenesis of the female reproductive system which causes endometriosis (EMS), recurrent spontaneous abortion (RSA), and polycystic ovary syndrome (PCOS). Accumulating studies have indicated that melatonin plays pleiotropic and essential roles in these obstetrical and gynecological disorders and would be a candidate therapeutic drug to regulate inflammation and immune function and protect special cells or organs. Here, we systematically review the pleiotropic roles of melatonin in EMS, RSA, and PCOS to explore its pathological implications and treatment potential.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b61a82673343de531dde30a7689c7f https://pubmed.ncbi.nlm.nih.gov/29493042 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.