The role of circulating extracellular vesicles in breast cancer classification and molecular subtyping
| Autor: | Khalid Al-Nedawi, Khrystyna Platko, Tariq Aziz, Sandor Haas-Neill |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Proteomics Receptor ErbB-2 ADAM12 Protein Breast Neoplasms Extracellular vesicles 030218 nuclear medicine & medical imaging 03 medical and health sciences Extracellular Vesicles 0302 clinical medicine Breast cancer Cell Line Tumor Plasminogen Activator Inhibitor 1 Internal Medicine Biomarkers Tumor Medicine Humans Stage (cooking) Pathological beta Catenin Aged Aged 80 and over business.industry Healthy subjects Estrogen Receptor alpha Middle Aged medicine.disease Immunohistochemistry Subtyping Oncology 030220 oncology & carcinogenesis Case-Control Studies Cancer research Surgery Female business Breast cancer classification Receptors Progesterone |
| Zdroj: | The breast journal. 25(4) |
| ISSN: | 1524-4741 |
| Popis: | Currently, tumor biopsies are used for breast cancer molecular subtyping. Biopsies are associated with various pathological changes and are thought to contribute to the dissemination of tumor cells. Extracellular vesicles shed by tumor cells into circulation exhibit the molecular signature of the parent cells. Herein, we show that proteomic analysis of circulating EV can discriminate BC patients from healthy subjects and indicate stage of the disease. Also, we performed a correlation between the BC molecular subtype using plasma EV and immunohistochemistry of tumor biopsies. Circulating EV may represent a useful, non-invasive tool to study the molecular makeup of BC tumors. |
| Databáze: | OpenAIRE |
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