Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats
| Autor: | Li-Sheng Chu, Yi-Lu Ye, San-Hua Fang, Meng-Ling Wang, Yu Zhou, Wei-Ping Zhang, Er-Qing Wei |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Leukotrienes medicine.medical_specialty Leukotriene B4 Ischemia Antioxidants Rats Sprague-Dawley chemistry.chemical_compound Caffeic Acids Atrophy Internal medicine medicine Caffeic acid Animals Pharmacology (medical) Cysteine cardiovascular diseases Neurons Pharmacology Leukotriene Arachidonate 5-Lipoxygenase biology business.industry Brain Infarction Middle Cerebral Artery General Medicine medicine.disease Rats Neuroprotective Agents medicine.anatomical_structure Endocrinology chemistry Ischemic Attack Transient Anesthesia Arachidonate 5-lipoxygenase biology.protein Neuron business Astrocyte |
| Zdroj: | Acta Pharmacologica Sinica. 27:1103-1110 |
| ISSN: | 1745-7254 1671-4083 |
| DOI: | 10.1111/j.1745-7254.2006.00406.x |
| Popis: | Aim: To investigate the effects of caffeic acid on early and delayed injuries after focal cerebral ischemia in rats, and the possible relation to 5-lipoxygenase inhibition. Methods: Transient focal cerebral ischemia was induced by middle cerebral artery occlusion in Sprague-Dawley rats. Caffeic acid (10 and 50 mg/kg) was ip injected for 5 d after ischemia. The brain injuries were observed, and the levels of cysteinyl leukotrienes and leukotriene B4 in the brain tissue were measured. Results: Caffeic acid (50 mg/kg) ameliorated neurological dysfunction and neuron loss, and decreased infarct volume 24 h after ischemia; it attenuated brain atrophy, infarct volume, and particularly astrocyte proliferation 14 d after ischemia. In addition, it reduced the production of leukotrienes (5-lipoxygenase metabolites) in the ischemic hemispheres 3 h and 7 d after ischemia. Conclusion: Caffeic acid has protective effect on both early and delayed injuries after focal cerebral ischemia in rats; and this effect may partly relate to 5-lipoxygenase inhibition. |
| Databáze: | OpenAIRE |
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