Complete nucleotide sequence of hepatic 5-aminolaevulinate synthase precursor
| Autor: | Byron A. Pirola, Mark A. Snoswell, Iain A. Borthwick, Brian K. May, Gopesh Srivastava, Adrienne R. Day, W.H. Elliott |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
chemistry.chemical_classification
Enzyme Precursors ATP synthase Base Sequence Protein primary structure Nucleic acid sequence Mitochondria Liver Chick Embryo DNA Mitochondrion Biology Biochemistry Peptide Fragments Amino acid Enzyme chemistry Mitochondrial matrix biology.protein Animals Amino Acid Sequence Cloning Molecular Peptide sequence 5-Aminolevulinate Synthetase |
| Zdroj: | European journal of biochemistry. 150(3) |
| ISSN: | 0014-2956 |
| Popis: | Chick embryo liver mitochondrial matrix protein, 5-aminolaevulinate synthase, is synthesised initially as a larger cytosolic precursor. In this report we present the complete nucleotide sequence of a cDNA clone coding for the precursor together with corresponding confirmatory amino acid sequence of peptides derived from purified mature mitochondrial enzyme. The deduced amino acid sequence shows that the precursor consists of mature enzyme of 579 amino acids and an N-terminal extension of 56 amino acids. The latter presequence is highly basic in character as found with other mitochondrial preproteins. |
| Databáze: | OpenAIRE |
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