DOES IT WORK? -a randomized controlled trial to test the efficacy of HCV and HIV-related education on drug users in MMT, China

Autor: Jingying Zhang, Jun Wang, Le Ping Huang, Zhi Bin Li, Min Zhao, Zhu Li, Gui Lai Zhan, Lei Zhang, Jiang Du
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Health Knowledge
Attitudes
Practice
HIV Infections
Hepacivirus
Efficiency
Organizational
law.invention
0302 clinical medicine
Randomized controlled trial
law
Surveys and Questionnaires
Prevalence
Cluster Analysis
030212 general & internal medicine
virus diseases
Hepatitis C
Awareness
Middle Aged
MMT
Treatment Outcome
Knowledge
Infectious Diseases
Drug users
HCV
Female
Research Article
medicine.drug
Adult
China
medicine.medical_specialty
Methadone maintenance
030106 microbiology
Disease cluster
Infection awareness
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Patient Education as Topic
Intervention (counseling)
Opiate Substitution Treatment
medicine
Humans
lcsh:RC109-216
Hepatitis
business.industry
HIV
medicine.disease
Mental health
Family medicine
business
Methadone
Zdroj: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019)
BMC Infectious Diseases
ISSN: 1471-2334
Popis: Background HCV (Hepatitis C virus) is a prevalent chronic disease with potentially deadly consequences, especially for drug users. However, there are no special HCV or HIV (human immunodeficiency virus)-related intervention programs that are tailored for drug users in China; to fill this gap, the purpose of this study was to explore HCV and HIV-related knowledge among drug users in MMT (methadone maintenance treatment) sites of China and to investigate the effectiveness of HCV and HIV-related education for improving the knowledge of IDUs (injection drug users) and their awareness of infection. Methods The study was a randomized cluster controlled trial that compared a usual care group to a usual care plus HCV/HIV-REP (HCV/HIV-Reduction Education Program) group with a 24-week follow-up. The self-designed questionnaires, the HCV- and HIV-related knowledge questionnaire and the HIV/HCV infection awareness questionnaire, were used to collect the data. Four MMT clinics were selected for this project; two MMT clinics were randomly assigned to the research group, with subjects receiving their usual care plus HCV/HIV-REP, and the remaining two MMT clinics were the control group, with subjects receiving their usual care over 12 weeks. Sixty patients were recruited from each MMT clinic. A total of 240 patients were recruited. Follow-up studies were conducted at the end of the 12th week and the 24th week after the intervention. Results At baseline, the mean score (out of 20 possible correct answers) for HCV knowledge among the patients in the group receiving the intervention was 6.51 (SD = 3.5), and it was 20.57 (SD = 6.54) for HIV knowledge (out of 45 correct answers) and 8.35 (SD = 2.8) for HIV/HCV infection awareness (out of 20 correct answers). At the 12-week and 24-week follow-up assessments, the research group showed a greater increase in HCV−/HIV-related knowledge (group × time effect, F = 37.444/11.281, P 0.05). Conclusion An MMT-based HCV/HIV intervention program could be used to improve patient knowledge of HCV and HIV prevention, but more effort should be devoted to HIV/HCV infection awareness. Trial registration Protocols for this study were approved by institution review board (IRB) of Shanghai Mental Health Center (IRB:2009036), and registered in U.S national institutes of health (http://www.clinicaltrials.gov, NCT01647191). Registered 23 July 2012.
Databáze: OpenAIRE
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